29 results
2.1 Primary objectiveTo determine patterns of response in the transvalvular pressure gradient while altering transvalvular flow.2.2 Secondary objectives-To quantify any added value or differentiation from stress assessment of aortic stenosis…
Primary objective: To validate the quantification of AR by time-densitometry on contrast aortography with the gold standard of CMRI measurements in order to refine the interpretation and evaluate the accuracy of the qRA method. Secondary objective:…
To determine normal FDG-uptake around PHV*s in aortic position.
To study the biological variation of cardiac biomarkers (e.g. cardiac troponin T and I, NT-pro-BNP, ST-2, Galectin-3) in clinically stable moderate aortic valve stenosis.
To determine the effects of surgical and transcatheter (transapical, transfemoral or transaortal) aortic valve replacement on patient neuropsychological functioning which provides the opportunity to prematurely establish subclinical effects that may…
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
To determine normal values in stress echocardiographic parameters in asymptomatic patients at least 6 months after successful MV repair for organic MV regurgitation. These normal values for non-invasive 2D stress echo testing are of utmost…
The main objective of the single center, observational study is to assess the immediate and long term effects of TAVI on LVF and coronary flow by means of pressure volume loops, intracoronary flow assessment, echocardiography and cardiac MRI/CT.…
This study is aimed at evaluate whether the microTEE can be used in stead of the current TEE probe, or intracardiac ultrasound catheters (ICE) in adults with a structural heart disease. The aim of the study is to compare image quality, the workflow…
The main objective of the single center, observational study is to assess the immediate and long term effects of TAVI on biomarkers, correlated to clinical outcomes.
To evaluate the effects of MitraClip implantation on:* mitral inflow patterns during exercise* the atrial septum, moreover the persistence of the iatrogenic atrial septal defect and the consequential risk of right atrial and ventricular dilatation…
The objective is to assess the degree of under- and overexpansion and malapposition of the CRS after implantation, and to come with a proposal of sizing based upon observations made in a (large) prospective clinical data set-experience. For this…
Evaluation of the morbidity and mortality rate at 3 and 12 month follow-up in patients implanted with Freedom SOLO prosthesis.
Primary Objective: The association between the functional improvement (change in VO2 max) and DSE parameters will be determined. In this way the diagnostic characteristics of DSE will be investigated.Secondary Objective(s): The influence of the…
The exact mechanism behind the observed fast recellularization of the DTEHV constructs is still unknown. A reasonable explanation might be that scaffold remnants inside the tissue-engineered constructs recruit the circulating blood cells. In order…
Primary objective: The primary objective of this non-randomized intervention trial is to investigate whether TAVR improves exercise capacity in patients with preserved LVEF and NF/LG or LF/LG severe AS reclassified based on hybrid CT/TTE-derived…
Primary objectives of the study are: 1. Defining the optimal image acquisition time window after FDG injection for PET/CT imaging in patients suspected of endocarditis2. Assessing the impact of gating (respiratory and ECG) on PET/CT image quality in…
The primary objective of this study is to describe and to quantify the change in cardiac mechanoenergetics, expressed by PVL monitoring (reflected by the parameters stroke work, potential energy and pressure-volume area), in patients undergoing…
The INVA-SOUND-MRI (INVAsive, ultraSOUND and MRI assessment of transvalvular gradients after transcatheter aortic valve implantation) study aims to elucidate: 1) The accuracy of transaortic gradient assessment with different modalities (invasive,…
The goal of this study is to demonstrate the value of SAVI (both non-invasive and invasive) in patients with moderate aortic stenosis. The short-term objective will compare SAVI with standard resting indexes for symptom burden, functional capacity,…