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Linear catheter ablation by DC-shock

The purpose of this study is to investigate the applicability of this method of ablation in human patients.The investigation will be conducted in patients with persistent atrial fibrillation who, with use of the current method (RF-ablation), can…

ACT Catheter System in Atrial Flutter, Advanced Cardiac Therapeutics: CE Trial Clinical Study

This study is intended to assess the safety and performance of the ACT Catheter for ablation of right atrial isthmus dependent flutter, also known as typical atrial flutter.

Feasibility trial of a staged epicardial and endocardial approach for treatment of patients with persistent or long standing persistent atrial fibrillation with radiofrequency ablation

To assess the safety and technical feasibility of treating subjects with Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation in a minimally invasive thoracoscopic ablation procedure utilizing the AtriCure Bipolar System,…

Place of Reveal® In the peri-operative aSsessment of patients undergoing Major vascular surgery (PRISM2).

1. To capture (true) arrhythmic episodes in patients after a major vascular surgery procedure.

ELectroanatomic substrate-guided STereotactic Ablative Radiotherapy for refractory Ventricular Tachycardia

Number of patients with >=80% reduction of VT burden, i.e., any ICD-treated or highly-symptomatic VT episodes, at one year after STAR compared to the year before (including VTs during the 8 week-blanking period). Efficacy parameters will be…

A prospective, randomized, multicenter study of flecainide acetate oral inhalation solution in single and repeat dose regimens for acute conversion to sinus rhythm (SR) in subjects with recent onset of symptomatic paroxysmal atrial fibrillation (AF).

The objective of this study is to evaluate the safety, tolerability and efficacy of single and repeat doses of flecainide acetate oral inhalation solution in patients with paroxysmal AF.

Stereotactic Arrhythmia Radiotherapy in the Netherlands no. 2

To confirm our STARNL-1 pilot efficacy and safety data in a larger cohort and obtain insights in the mechanism of action by evaluating electro-anatomical alterations of stereotactic arrhythmia radiotherapy in patients with therapy refractory…

MiniImal Defibrillation Threshold in With a Subcutaneous Implantable-Defibrillator Patients Undergoing Elective Generator Replacement.

To determine the lowest energy which successfully converts induced ventricular arrhythmias in S-ICD patients who underwent elective generator replacement and compare these data to average DFT results in de novo S-ICD patients from previous studies.

Stereotactic Arrhythmia Radiotherapy in the Netherlands no. 1

To evaluate the efficacy and safety of stereotactic arrhythmia radiotherapy in patients with therapy refractory ventricular tachycardia.

TIBOHCA: A phase II study to evaluate the safety, tolerability and pharmacokinetics of 2-Iminobiotin (2-IB) after out of hospital cardiac arrest

The primary objective of this study is to evaluate the short term safety and tolerability, and pharmacokinetic properties of 2-IB when administered to adult patients after OHCA. Secondary objectives include safety and efficacy parameters at 30 days…

AF Septal pacing

Primary Objective: To evaluate the feasibility to obtain a stable position of a ring of stimulation electrodes on the interatrial septum.Secondary objective: *Localized Atrial Capture: evaluate if during the rapid pacing phase of the dual-stage…