258 results
To demonstrate superiority of left ventricular septal pacing over right ventricular pacing and to investigate the additional effect of capturing the left bundle branch in left ventricular septal pacing (LVsP). This will be done by studying…
The primary objective of the TactiFlex PAF IDE clinical trial is to demonstrate that ablation with the TactiFlex* Ablation Catheter, Sensor-Enabled* (TactiFlex SE), in conjunction with a compatible RF generator and three-dimensional mapping system,…
Objective of the study is to measure dabigatran trough levels, percentage of dabigatran glucuronidation, and diluted thrombin time, to test whether these levels are different in elderly patients.
Primary Objective: To prospectively identify parameters correlated with Cerebral Performance Category (CPC)* * 2 at hospital discharge. Secondary Objective(s): - Parameters correlated with a CPC*1 * 2, 6 months after arrest- Parameters correlated…
The objective of this study is to determine the performance, as defined by sensitivity and specificity, of the commercially available Apple Watch-based electrocardiographic registration to identify AF during tachycardia, validated against the gold…
Primary ObjectiveThe goal of the study is to evaluate hemostasis (i.e. coagulation activation, platelet reactivity, overall thrombus formation and fibrinolysis) following LAAO in a longitudinal design for hypothesis-generating purposes. Several…
To determine the ratio of parent drug to metabolites in the circulation.Profiling of [14C]-etripamil metabolites in blood, urine and feces.To determine the mass balance of drug-related materials following intranasal administration.To determine the…
Primary:1. The primary objective is to evaluate the safety of self-administered etripamil nasal spray (NS) outside of the clinical settingSecondary Objectives:1. To evaluate the efficacy of self-administered etripamil NS outside of the clinical…
Primary Objective The primary objective of this pilot study is to assess the ability of MV sensor driven rate adaptive atrial stimulation to restore the quality of life in CI heart failure patients.Secondary Objective(s)The secondary objectives of…
Primary Objective: The primary objective of the pilot study is to evaluate the feasibility and acute efficacy of irreversible electroporation for pulmonary vein antrum isolation in patients with atrial fibrillation:- Acute pulmonary vein isolation…
Primary objective of this study is to investigate the possible correlation between non-invasive strain(rate) measurements with speckle tracking in the left atrium and invasive voltage measurements in the left atrium. Secondary abjectives are to…
Safety and feasibility of IRE for PVI
The primary objective of the study is:- to evaluate the burden of AF and quality of life rhythm after thoracoscopic ablation surgery and after port-access concomitant left atrial MAZE surgery by continuous rhythm monitoring (Medtronic Reveal Linq…
To determine a risk profile based on clinical correlates, circulating biomarkers, and genetic background associated with failure of the hybrid AF ablation procedure.
The FAST Therapy Trial is a prospective trial of patients with a new diagnosis of fetal SVA aimed to compare the impact of different perinatal treatment strategies from the time of SVA diagnosis to birth or death1) The primary outcome will be the…
The study will gain information on 3D movements / curvatures of the Reliance 4-Front and Reliance 4-Site ICD leads in vivo. We expect that the movements will be influenced by the type of lead (lead stiffness, which is different between the 2 lead…
To validate the use of the Livv Mobiel ECG as a reliable office/bedside screening tool in primary care practice
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presentingwith Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation utilizing the…
To demonstrate the safety and effectiveness of the IntellaNav StablePoint Catheter and Force Sensing System with DIRECTSENSE for treatment of drug refractory, recurrent, symptomatic Paroxysmal Atrial Fibrillation (PAF).
The purpose of this study is to evaluate the safety and effectiveness of the Aveir wireless dual-chamber pacemaker system in the treatment of patients with slow or irregular heartbeats.