258 results
To establish the safety and effectiveness of the Boston Scientific Cardiac Cryoablation System for treatment of symptomatic, drug refractory, recurrent, paroxysmal atrial fibrillation (AF).
Primary Objective:* The primary objective of this study is to determine the influence of different anatomical positions on step 2 of the PRAETORIAN score.Secondary Objective(s):* The influence of the different anatomical positions on the total…
To gather electrocardiogram, pulse oximeter and heart rate analog front-end, accelerometer and temperature data of patients undergoing electrical carioversion (ECV) for the treatment of AF, and to use the data for the training and validation of Afi…
The objective of this study is to evaluate the safety, tolerability and efficacy of single and repeat doses of flecainide acetate oral inhalation solution in patients with paroxysmal AF.
To confirm our STARNL-1 pilot efficacy and safety data in a larger cohort and obtain insights in the mechanism of action by evaluating electro-anatomical alterations of stereotactic arrhythmia radiotherapy in patients with therapy refractory…
Aim: To determine the specificity and sensitivity of the AF app to detect AF.
The primary objective of this study is to characterize low-voltage substrate, as identified via HD Wave mapping in sinus rhythm and identify associations with 12-month recurrence rates after a single pulmonary vein isolation with a contact force RF…
The objective of this study is to determine the performance, as defined by sensitivity to detect AF and specificity to detect SR, of the commercially available Apple Watch-based electrocardiographic rhythm classification algorithm, validated against…
Non-invasive localization of the origin of idiopathic ventricular arrhythmias
Evaluation of the AF detection performance of the BioMonitor III ICM in patients who are scheduled for a PVI in comparison to simultaneous Holter monitoring.
The primary objective of this study is to identify atrial tissue miRNAs that are associated with the incidence of AF and histological alterations in a population of patients without documented AF. Secondarily, this study will validate AF associated…
The primary objective is to examine the impact of t-LLVS on electrophysiological properties of the atria and ventricles. Secondary objectives are:- to elucidate the correlation between proteostasis marker levels in serum and atrial tissue, and the…
Primary objective:To evaluate the clinical efficacy and side effects (adverse events) of a single dose stereotactic radiotherapy on the electro-anatomical arrhythmia substrate, inaccessible by the current state of the art catheter ablation…
This pilot study sets out to assess stimulation-evoked PESP-BP using various stimulation protocols and to compare outcomes with PESP-BP by spontaneous ESB. Moreover, we aim to derive a stimulation protocol for PESP-BP assessment, which can be used…
To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.
To study whether epigenetic profiles of study participants who suffered an out-of-hospital cardiac arrest (OHCA) that were collected immediately after OHCA (in ARREST biobank) are similar their epigenetic profiles collected at least 9 months after…
The objective of the study is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI* or Endurity MRI* pacemakers, in patients undergoing clinically indicated 3T MRI scans.
To identify predictors of success of AF ablation including clinical factors, AF recurrence patterns, anatomical and electrophysiological characteristics, circulating biomarkers and individual genetic background.
The main goals of this study are to study the effects of VHPSD ablation on the duration of a pulmonary vein isolation procedure, and on transient (edema) and persistent (fibrosis) effects of VHPSD ablation in the left atrial wall.
The VOLT AF First-in-Human (FIH) study will collect feasibility data to show that the Volt PFA System functions as intended in a clinical setting and to demonstrate acute safety and effectiveness for the treatment of symptomatic, recurrent…