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Expression of cytokeratins and notch in the healthy folliculopilosebaceous unit

1) to examine the expression of cytokeratins and Notch in healthy human FPSUs at different segments. 2) to describe the association between expression of the cytokeratins and Notch 1 in the FPSUs of healthy volunteers.

A prospective *proof of concept study* to evaluate the potential efficacy of ustekinumab in patients with moderate to severe hidradenitis suppurativa (acne ectopica)

Primary objective: 1. To evaluate the effect of ustekinumab in patients with moderate to severe hidradenitis suppurativa (Hurley II-III), measured by disease specific score systmes: Sartorius/HS-LASI and PGA 2. To evaluate possible changes in scores…

Monitoring Skin Immune System (SIS) alterations in HS during treatment with biologics.

To investigate the changes in the skin immune system after 12 weeks of biologic therapy treatment in patients with HS.

Genetics of hidradenitis suppurativa

To determine which gen defects are associated with hidradenitis suppurativa.

Exome Sequencing and Molecular Profiling in Patients with Hidradenitis Suppurativa (HS)

To Identify genetic variants and clinical phenotypes associated with risk of HS and to characterize the key cellular and molecular mechanisms and pathways involved in the pathogenesis of moderate-to-severe HS.

Abscess drainage in Hidradenitis Suppurativa: Incision and Drainage versus Punch Debridement

This randomized-control trial is designed to determine the recurrence rate of HS abscesses following drainage via two methods: I&D with a linear incision and PD with an 8mm punch biopsy. In this context, recurrence is a newly described HS…