555 results
This study has been transitioned to CTIS with ID 2024-515832-59-00 check the CTIS register for the current data. To assess the long-term safety and tolerability of treatment with efgartigimod PH20 SC in participants with BP
In this proposal, we therefore aim to characterize in detail the cutaneous B cell response in patients with isolated CLE (CLE only) and patients with systemic and cutaneous disease (SLE/CLE). Primary Objectives: 1. Characterize autoreactive B cells…
The primary objective of this study is to collect blood samples (maximum of 150 mL per study visit ) from women and men who have SLE and from volunteers in good health to study the immune system of SLE patients and to investigate new potential…
We aim to describe the clinical characteristics and immune response in children seeking care for post-COVID complaints. Moreover, in a subset of children we evaluate the effect of the reinfection on clinical and inflammatory outcomes in children…
This study has been transitioned to CTIS with ID 2023-509710-11-00 check the CTIS register for the current data. Study Objectives:The purpose of this Phase 2 study is to evaluate the safety, efficacy, pharmacokinetics (PK),pharmacodynamics (PD), and…
Primary objectives: To develop and internally validate a novel and interpretable machine learning model for detecting flare in PsA patients using integrated accelerometer data, keystroke dynamics and screen time metrics (i.e., digital…
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…
This study has been transitioned to CTIS with ID 2024-515703-19-00 check the CTIS register for the current data. The objectives of this follow-up study of the EPITOPE study are:• To assess the clinical benefit of Viaskin Peanut after up to 3 years…
We aim to define the growth trajectory of clonal hematopoësis after allogeneic transplantation, and identify potential modulating factors.
Current laboratory tests for hypersensitivity are not sensitive of do not exist for certain allergens omong which medical drugs. To objective is therefore to optimize existing in vitro tests (lymphocyte activation and proliferation test, cytokine…
• To evaluate the response to an in vivo immune challenge (KLH) in RA patients in responders versus non-responders to MTX therapy.• To evaluate the immune status of RA patients before and after the start of MTX therapy using an ex vivo immune…
We hypothesize that during an episode of immune-mediated organ specific toxicity, as a result of inflammation and damage to the specific organ, organ-derived DNA will be detectable in blood of patients. The aim of this project is to investigate…
The primary objective of this study is to determine if medication allergy sensitization can be accurately determined through a laboratory test with a patients* blood sample. The secondary objective is to develop a laboratory assay that can be…
Primary objective: To assess the long-term effect of treatment with lebrikizumab on the overall well-being in patients with moderate-to-severe AD using the WHO-5 questionnaire. Secondary objectives: To assess the clinical effectiveness of…
Primary Objective: - Evaluate changes in immune response during oral immunotherapy with either peanut or baked milk in children with a mild peanut or cow*s milk allergySecondary Objective: - Compare the immunological changes at baseline and over…