353 results
Primary Objective:* To evaluate the long-term safety of efgartigimod in adult patients with primary immune thrombocytopenia (ITP).Secondary Objectives:First 52-week treatment period only:* To evaluate the long-term efficacy of efgartigimod on…
The main goal is to define whether macrophages from patients with AGN induce T-cell activation and migration due to their pro-inflammatory phenotype.
Primary: The safety and tolerability of BIVV020Secondary: - The effect of BIVV020 on complement mediated hemolysis.- The pharmacodynamics (PD) of BIVV020 relating to complement inhibition.- The pharmacokinetics (PK) of BIVV020.- The immunogenicity…
To assess long-term safety, tolerability and efficacy of upadacitinib in adult subjects with moderate to severe atopic dermatitis who successfully completed treatment in the M16-046 study. Efficacy will be evaluated through Week 52, and safety and…
Objective: I) Test the ability of JPAST (Joint Pain Assessment Scoring Tool) to discriminate patients with and without rheumatic musculoskeletal diseases (RMDs) in patients referred to the rheumatology outpatient clinic. II) Compare the JPAST*s…
The primary objective of this study is:- To evaluate the long-term safety of fostamatinib in subjects with warm antibody autoimmune hemolytic anemia (wAIHA)The secondary objectives of this study are:-To compare the proportion of subjects with wAIHA…
This study has been transitioned to CTIS with ID 2023-505699-31-00 check the CTIS register for the current data. To evaluate the Long-Term Safety and Efficacy of upadacitinib.
The primary objective of this open-label extension (OLE) study is to assess the long-term safety and tolerability of bimekizumab administered over a period of up to 112 weeks.
The primary objectives of this study are to evaluate advanced MRI techniques (IVIM, T2*-mapping, motility) and advanced ultrasound techniques (CEUS, SWE and SICUS) to: 1. Identify advanced imaging techniques that correlate with stricture composition…
This non-interventional, observational cohort study, aims to standardize the assessment of disease activity in all JIA patients and correlate this to systematically acquired clinical, environmental and laboratory derived data. Ultimately, these data…
Main objective:- To evaluate the long-term safety and tolerability of ARGX-113 in acetylcholine receptor antibody (AChR-Ab) seropositive patients.Secondary objective:- To evaluate the long-term safety and tolerability of ARGX-113 in the overall…
To evaluate possible changes in immune profiles and platelet function after start of a TPO-RA.
- to investigate different cellular, molecular, genetic and epigenetic pathogenic mechanisms in synovial tissue leading to the various inflammatory joint diseases- to investigate these changes in the synovial tissue in relationship to the duration…
We hypothesize that during an episode of immune-mediated organ specific toxicity, as a result of inflammation and damage to the specific organ, organ-derived DNA will be detectable in blood of patients. The aim of this project is to investigate…
The primary goal of this study is to compare serial paired POC and venous INR measuremtents and to distill an individual conversion factor per patient, enabling the ungoing use of POC-INR measurement also in this patient group.
In this research proposal, we aim to develop chemical reporter molecules to study neutrophil activity and NET formation in real-time. We will systematically study the effect of brain-associated amyloid fibrils on NET formation and investigate the…
Primary Objectives: To unravel the immunological characteristics of postoperative recurrent CD and study the immunological changes in the IL-23 pathway following treatment with biological agents.Secondary Objectives:To study clinical, endoscopic and…
Primary Objectives: * to establish - which is the best treatment, MTX or baricitinib, to ensure rapid symptom relief of recent onset UA, based on clinical and patient reported outcomes from baseline to 3 months. Secondary Objective: * to establish…
The main objective of this study is to determine how well the Multiple Screener© can differentiate between patients with no cognitive deficits, mild cognitive deficits and cognitive impairment. Additionally, we aim to confirm the observed accuracy…
This study has been transitioned to CTIS with ID 2023-510210-68-00 check the CTIS register for the current data. Primary objective:- To assess the long-term safety and tolerability in patients with cold agglutinin disease (CAD), after multiple doses…