353 results
The purpose of this study is to investigate how quickly and to what extent the new compound BMS-986165 is absorbed and eliminated from the body (this is called pharmacokinetics) when it is administered to healthy volunteers without and with…
Primary objective: study the association of circulating iNKT cell numbers and function with early atherogenesis, as measured by cardiovascular magnetic resonance imaging (MRI). Secondary objectives: a) study the association of circulating iNKT cell…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
The aim of this study is to characterize the in vitro properties of platelets and autoantibodies of adult patients with primary/chronic ITP, in order to gain insight in the molecular mechanisms underlying the disease. This may lead to development of…
The purpose of this study is to compare administration of efgartigimod under the skin (subcutaneously/SC) to administration directly into a blood vessel (intravenously/IV). This is being studied to compare if subcutaneous injection is equally safe…
The sponsor is developing a compound (PB006) similar to Tysabri® (natalizumab, hereafter referred to as Tysabri). As part of medical-scientific studies to confirm the similarity of the two compounds, the Sponsor wants to compare PB006 with EU-…
The objective of our study is i) to verify the *silent* joint paradigm: to assess the TMJ using MR imaging in children with new onset not yet treated JIA, without clinical signs and symptoms indicating TMJ arthritis; ii) to assess the utility of…
Study Objectives:* To monitor the long-term safety profile of NI-0501* To assess HLH patients* survival after NI-0501 treatment* To assess duration of response to NI-0501 treatment (i.e. maintenance of HLH control)* To assess post-HSCT outcome…
To explore the effects of HBOT on immunologic parameters and oxidative stress.
General- To determine the safety of OTL38 in IBD and rheumatoid arthritis patients by monitoring of vital signs during tracer infusion and evaluating possible (severe) adverse events (SAE/AEs).RA- To determine the feasibility of molecular…
The purpose of this study is to investigate how quickly and to what extent LNP023 is absorbed, broken down, and eliminated from the body (this is called pharmacokinetics). LNP023 will be labelled with 14 carbon (14C) and is thus radioactive. In this…
The aim of this study is to describe pharmacokinetic parameters of the following golimumab regimens: 50 mg every month, 100 mg every one-and-a-half month and 100 mg every two months, in patients with a rheumatic disease.
The purpose of this study is to investigate how quickly and to what extent LOU064 is absorbed, broken down, and eliminated from the body. LOU064 will be labeled with 14 carbon (14C) and is thus radioactive. In this way LOU064 can be traced in blood…
1. To compare the proinflammatory, profibrotic and osteogenic cytokine profile in BAL fluid between SSc patients without ILD, with limited ILD, and with extensive ILD.2. To compare the proinflammatory, profibrotic and osteogenic differentiation of…
The primary objective of this study is to identify ultrasonographic parameters that indicate response to treatment in moderate to severe UC. Accordingly, a secondary objective is to create an ultrasonographic scoring model which predicts response.
Find/confirm percentage of remission after discontinuing TPO-RA in persistent and chronic ITP patients.
Primary objectives:To develop and internally validate a novel and interpretable machine learning model for detecting flare in PsA patients using integrated accelerometer data, keystroke dynamics and screen time metrics (i.e., digital biomarker) to…
The aim of this study is to evaluate the AUC, disease status, presence of ADAbs and treatment burden when switching from IV to SC IFX maintenance treatment in a real-world cohort of IBD patients on IFX monotherapy and combination therapy.
To gain a better understanding of NET formation by human neutrophils and the molecular mechanisms underlying this process.We would like to gain insight in:* The differences in NET formation upon the exposure of neutrophils to different stimuli.* The…
Primary Objective: To investigate diastolic LV dysfunction before and after 6 months anti-inflammatory treatment with TNF blockers in patients with RA, assessed by exercise-stress echocardiography.Secondary Objective: To investigate whether systolic…