353 results
The objective of the study is to gather as many DNA samples of partners of IBD patients and parents of adult IBD patients as possible. By assessing allele and genotype frequencies in IBD patients and the control cohort, novel genetic risk factors…
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In this research the effects of Type D and mindfulness on psychological well-being and physical functioning is reported in two different treatment groups. Rheumatoid arthritis is a chronic disease. Personality could be an important factor in…
Construction of a biobank of peripheral blood and skin biopsies from patients with SLE, to evaluate gene polymorphisms, gene expression profiles, new antigens and/or antibodies and to store material for analysis in future in case of newly discovered…
The objective of this study is to investigate whether there is a change in lipids and bonemarkers and what the frequency of occurence of (riskfactors for) cardiovascular disease, osteoporosis and antibodies during treatment with rituximab.
Evaluation of the effect of retreatment with rituximab in 20 patients with primary Sjögren syndrome, and evaluation of the intra-individual effect of rituximab compared to placebo, in 10 patients who received placebo in the double blind randomized…
-To evaluate the effects of IVIg on the humoral and cellular immune system.-To identify biomarkers which are associated with the effect (on muscle strength and sensory modalities) of IVIg. To investigate the value of these biomarkers in other…
To assess the long-term safety and tolerability (and in particular the infection occurrence) ofACZ885 in patients with rheumatoid arthritis (RA) who participated in the core CACZ885A2204,CACZ885A2206, or CACZ885A2207 studies.
Objectives:To assess the safety of transitioning subjects to Raptiva therapy from standard oral systemic or phototherapy by overlapping with Raptiva whilst tapering the initial systemic therapy or phototherapy dose. The secondary objective is to…
- To investigate different pathogenetic mechanisms underlying the clinical syndrome termed RA - To investigate changes in the synovial tissue in relationship to the duration of disease- To identify new therapeutic targets in the synovial tissue in…
Investigating the safety of adalimumab when administered in subjects with Crohn*s Disease as well as evaulating the efficacy of adalimumab for the induction and maintenance of clinical remission and fistula closure in subjects with moderate to…
We think that HIF1α could be an important driving force in ongoing angiogenesis and inflammation as seen in RA. If this is the case HIF1α could be an important therapeutic target in RA.In the present study we plan to include patients with early RA…
to evaluate the safety and efficacy of ECP as adjunct first-line therapy in patients with newly diagnosed chronic GVHD of the liver or lungs
objective
To collect and store a serum sample of each patient that is referred to the Leiden University Medical Centre for evaluation of neuropsychiatric symptoms in SLE.
The primary objective of this study is to evaluate the humoral response to influenza, pneumococcal and hepatitis B vaccination in patients with rheumatic autoimmune diseases (reumatoide artritis and poly- dermato-myositis) treated with…
The primary objective of the trial is to study the efficacccy of sirolimus in paraneoplastisch neurological syndromes associated with anti-Hu antibodies (Hu-PNS)Secondary objectives are to correlate clinical improvement with anti-Hu antibody titers…
The objectives of this study are to finalize and validate the preliminary RAID.
The purpose of this study is to investigate the association between T cell compartment composition and vitamin D status in MS patients, with particular interest for regulatory T cell functionality.
The primary purpose is validation of the dutch version of a brief health-related quality of life (HRQOL) tool in children with systemic lupus erythematosus (SLE). This tool is called *Simple Measure of Impact of Lupus Erythematosus in Youngsters© (…