12 results
The primary objective is to investigate quality of life after switch to a combination therapy including boosted DRV and DTG. Secondary objectives are to investigate 1) the residual viral replication, 2) level of virus production from infected cells…
Primary: to investigate the most importants determinants of the viral dynamics of low-level viremia. Secondary: to investigate the effects on immune activation, neurocognitive performance and periodontal status.
The primary objective of this study is to explore if (and which) HIV-specific CTL responses shorten the lifespan of productively infected cells in HIV-infected individuals. This will be accomplished by investigating the estimated life spans of…
To assess the ex vivo cytokine production of whole blood during 28 days after phlebotomy (routine withdrawal of 500 ml of blood).
We will test a new theoretical model that assumes that mental health status interacts with the genetic factors influencing sympathovagal balance and the pro-inflammatory state. The results will be published in scientific magazines, and/or presented…
Using pedigree research in two CVID-families to find clues for genetic testing.
Primary Objective The prevalence and incidence of (pre)malignant and inflammatory pathology in the gastrointestinal tract of patients with a primary antibodydeficiency (CVID, XLA, IgG subclasse deficiency and abnormal vaccinationrespons). Secondary…
1. To study the possible association between MBL-deficiency and the occurence and severity of infections in MBL-deficient CF patients.2. To study the possible association between MBL-deficiency and the severity of cystic fibrosis.3. To study the…
With this study, we want to gain insight in the SARS-CoV-2 specific immunity (T- and B-cell) of patients with congenital immune disorders. This will add to our knowledge on SARS-CoV-2 specific immunity, and on the immune capacity of the patients…
In this study it is aimed to investigate the genetic and immunological causes of VEO-IBD in order to improve diagnostics and therapies for patients with this intractable disease. In an explorative approach, state-of-the-art genome-wide screenings on…
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…
To gain insight in clinical, virological and immunological mechanisms and predictors of the eradication of HIV. To gain insight in the dynamics of the T cell HIV reservoir in which HIV is persisting. To gain insight in different levels of immune…