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A Phase III Randomized Clinical Trial to Study the Efficacy and Safety of the Combination Regimen of MK-5172/MK-8742 in Treatment-Naïve Subjects with Chronic HCV GT1, GT4, and GT6 Infection who are on Opiate Substitution Therapy.

3.1 Primary Objective(s): 1) Objective: To evaluate the efficacy of MK-5172 in combination with MK-8742 as assessed by the proportion of subjects achieving SVR12 (Sustained Virologic Response 12 weeks after the end of all study therapy), defined as…

Repeated Controlled Human Hookworm Infection in Healthy Dutch Volunteers

Primary objective:* To determine the safety and tolerability of repeated infection of Necator americanus L3 larvae in healthy volunteersSecondary objectives:* To compare the variability in egg output after cumulative infection with 50, 100 and 150…

Can sweeteners encourage the growth of good bacteria? A clinical exploratory pilot study.

To study the effect of sweetener oral rinses on the oral microbiome composition.