116 results
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
The primary objective is to investigate quality of life after switch to a combination therapy including boosted DRV and DTG. Secondary objectives are to investigate 1) the residual viral replication, 2) level of virus production from infected cells…
Primary: to investigate the most importants determinants of the viral dynamics of low-level viremia. Secondary: to investigate the effects on immune activation, neurocognitive performance and periodontal status.
To estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially VAP, and to assess its association with patient-related and contextual factors, e.g. colonization status, serum antibody levels against S. aureus alpha toxin [AT],…
Objective of the study is to quantify the microbiological etiology in immunocompromised patients, at least 18 years of age, with CAP needing hospitalization. And to determine the severity, antibiotic use and outcome of CAP in immunocompromised…
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
The primary objective of this study is to monitor changes in oral health during a 3.5-month naval mission and once one month thereafter.
determine the effect of cold exposure on influenza induced immune responses
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
The aim of this research is to contribute to the understanding of the pathophysiology of severe infections, and subsequently providee relevant new insights in the development of new treatment modalities. In the present research proposal we would…
This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…
The primary objective of this study is to explore if (and which) HIV-specific CTL responses shorten the lifespan of productively infected cells in HIV-infected individuals. This will be accomplished by investigating the estimated life spans of…
Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.
The primary objective of the study is to evaluate the effects of orally administered metformin on the immune and metabolic responses of stimulated peripheral blood mononuclear cells (PBMC*s) and macrophages from healthy individuals.
1. Determine the relationship between periodontitis and HIV-related immune activation and hypercoagulability.2. Explore the role of oral microbiota as effect modificator of the relationship between periodontitis and immune activation in HIV-infected…
1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…
Primary objectives:1. To determine the effect of the use of a tailored intervention protocol (regarding reduced antimicrobial use, improving hygiene and changing the animal contact structure) on pig and veal farms on the degree of antimicrobial…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
Primary Objective: To investigate the presence of periodontitis in ACPA and or RF positive patients with arthralgia*s.Secondary Objective: to unravel the role of the cellular immune response in ACPA positive persons with arthralgia*s who are at risk…