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Effects of oxygen status on Hypoxia Inducible Factor 1-α. A pilot proof of principle study.

The primary objective of the study is to determine the effects of hyperoxia and hypoxia in healthy volunteers on kinetics of HIF1α mRNA in circulating leukocytes. Secondary objectives are to determine the effects of hyperoxia and hypoxia on HIF1α…

Absorption of tobramycin from the gut in critically ill patients treated with selective decontamination of the digestive tract (SDD)

To determine whether tobramycin, administered in the gut, permeates from the gut into the blood and is subsequently excreted into the urine.

FAME study: Fecal Administration for eradication of Multiresistant ESBL producing bacteria in carriers

The objective of the study is to see whether donor feces infusions can help to eradicate ESBL in patients who carry ESBL.

Resuscitation for repair of endothelial permeability in endotoxemia

The main objective of the proposed study is to investigate the effect of plasma products and albumin on markers of endothelial function in a human endotoxemia model.

Exposure to orally administered antibiotics during the initial phase of infection in non-critically ill, febrile patients

The primary objective is to determine whether the exposure to oral ciprofloxacin and amoxicillin is altered in hospitalized non-critically ill, febrile patients in need of IV antibiotics when they are acutely ill and febrile, compared to when they…

The tolerance to RISA root canal irrigation fluid determined in an in-vivo study

To assess the tolerance of RISA after its application in the root canal system during root canal treatment.