Search for a trial

Proof of Concept Study of Eurartesim® in Patients with Imported Uncomplicated Plasmodium Vivax Malaria

Primary Objective:• Uncorrected Adequate Clinical and Parasitological Response (ACPR) at Day 21.Secondary Objectives: • Proportion of aparasitaemic patients (at different visits).• Proportion of afebrile patients (at different visits).• Uncorrected…

Drug interactions between ATOvaquone used in MAlaria prophylaxis and antiretroviral agents in HIV-1 infected patients (ATOMA)

To determine the effect of antiretroviral agents (low-dose ritonavir + lopinavir, low-dose ritonavir + atazanavir, efavirenz) on the pharmacokinetics of single-dose atovaquone determined by intersubject comparison. Secondary objectives: - to…

A clinical study to assess the safety and feasibility of relapsing P. vivax controlled human malaria infection through experimental sporozoite infection of healthy malaria-naïve UK adults, and to characterise parasite growth and immune responses to primary and relapsing P. vivax infection

Primary ObjectiveTo assess the safety, feasibility and frequency of relapsing P. vivax PvW1 infection after experimental sporozoite-administered Controlled Human Malaria Infection (CHMI)Secondary ObjectivesTo assess the immune response to primary…