50 results
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
The primary objective is to investigate quality of life after switch to a combination therapy including boosted DRV and DTG. Secondary objectives are to investigate 1) the residual viral replication, 2) level of virus production from infected cells…
Primary: to investigate the most importants determinants of the viral dynamics of low-level viremia. Secondary: to investigate the effects on immune activation, neurocognitive performance and periodontal status.
determine the effect of cold exposure on influenza induced immune responses
This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…
The primary objective of this study is to explore if (and which) HIV-specific CTL responses shorten the lifespan of productively infected cells in HIV-infected individuals. This will be accomplished by investigating the estimated life spans of…
1. Determine the relationship between periodontitis and HIV-related immune activation and hypercoagulability.2. Explore the role of oral microbiota as effect modificator of the relationship between periodontitis and immune activation in HIV-infected…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
Objective: General objective: To improve and standardize assessment of risk behaviour and its behavioural correlates in HIV patients. Specific objectives: 1) To assess sexual risk behaviour in HIV patients, 2) to assess drug related risk behaviour…
Implement a survey initiative to assess HIV prevalence for one or more diseases and/or conditions within a specific segment of the population not yet diagnosed with HIV and that present for care with the specific disease/condition.
The aim of this study is to investigate the T cell immune system in relation to viral kinetics in acute HBV infection in order to obtain more insight into mechanisms of failure of viral control and development of chronic HBV infection, and to…
In this study we will for the first time combine in-vitro stimulation assays and high throughput sequencing to identify, quantify and phenotype the clones that play a functional role in influenza infections and follow them over time. This will lead…
a. To assess the burden of mumps in the student population.b. To describe the risk factors for mumps virus infection (symptomatic and asymptomatic). c. To determine the relative contribution of household transmission and transmission at the party to…
Evaluate the prevalence, consistency, and genotype distribution of human papillomavirus (HPV) in semen and to examine the exact localization of HPV (i.e., in the seminal fluid and/or on the membrane or cytoplasm of the sperm cell).Evaluate the…
Our hypothesis is: HBV interferes with the function of intrahepatic innate immune cells, especially NK cells. Since NK cells play a major role in anti-viral immunity and NK cells comprise a large proportion of the intrahepatic immune cells, we would…
2.1 Primary Objective• Evaluation of the levels of thrombophilic factors in the blood of HIV-infected patients before starting with cART and the changes of these levels when on cART for the time of one year. 2.2 Secondary Objective• Evaluation of…
* To study HIV-1 sequence dynamics and HIV-1 evolution in donor-recipient pairs in relation to host and viral factors.* To detect and characterize the differences in transmitted virus in donor-recipient pairs as soon as possible after transmission.
Determine associations between genetic variation and immune response in nasopharyngeal aspirates of infants with RSV LRTI.
Primary aimTo evaluate the effects of peginterferon and ribavirin therapy on the immune response in chronic HCV genotype 1 patients before, during and after treatment.Secondary aims1. To determine if differential modulation of Treg activity or DC…