41 results
The primary objective of this Registry is:• To evaluate HCV viral sequences and the persistence or evolution of treatment emergent viral mutations in subjects who fail to achieve an SVR after treatment with a Gilead oral antiviral containing regimen…
Study of the phenotype and function of NK cells obtained from peripheral blood and liver of patients who are successfully being treated for at least 3-4 years for their chronic HBV infection with tenofovir in a flow-up study (METC nr. 2008-271).
PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…
The primary objective of this Registry is:*To evaluate the long term effects of Hepatitis B Virus (HBV) treatment of the parental study on the HBV serologic changes through Week 144 The secondary objective of this Registry is :*To evaluate the long…
This study aims to identify global and local determinants of HPV vaccine acceptability, HPV vaccine uptake and compliance as well as identify logistics and programmatic issues in each country to offer the HPV vaccine, as a potential cervical cancer…
Recent studies demonstrate long-term durability of virologic response with pegylated alpha-interferon-based therapies. Comparable information is not yet available for Lambda or for regimens combining lambda interferons, RBV, and DAAs. In this…
To evaluate in detail the functionality of immune cells in blood in chronic HCV patients before, during and after treatment with ASV and DCV, in an IFN-free regimen.
• to describe the epidemiological trends of dengue infections imported to Europe by returning travelers• to describe the full clinical spectrum of dengue disease imported to Europe by returning travelers• to report the phylogeny, selection pressure…
The objective of the study is to investigate the association between IL28 SNPs and the outcome of acute HCV treatment (response or non-response) in HIV-infected patients.
To assess symptomatic and asymptomatic attack rate through the analysis of specific (IgG) antibody responses prior to, and in response to mumps virus infection; Secondary: to estimate a serological correlate for immune protection against symptomatic…
The primary aim of our study is to link stated preferences of parents of newborn children for hepatitis B vaccination to actual vaccination behaviour. The secondary objective is to determine the external validity of the Discrete Choice Experiment as…
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
Objective: Using an animal model for measles, we have recently developed a hypothesis to explain the mechanism of measles immune suppression (De Vries et al., PLoS Pathogens 8:e1002885, 2012). We hypothesize that MV causes massive infection and…
Primary objective:A. Development of human monoclonal antibody or combination thereof for the treatment of Rabiës and Rabiës-like viruses that might provide an affordable and accessible alternative to current polyclonal preparations. Particular…
the primary objective is to investigate if HIV-infected patients treated with a NNRTI display higher peripheral T cell apoptosis than those treated with a PI. Secondary objectives are to investigate 1) which apoptosis pathway is involved in…
To assess the prevalence of (recent) hiv infections, hepatitis B and C, and (related) risk behaviour among detainees in PI the Geerhorst, Southern Limburg in the Netherlands.
To gain insight into the prevalence of HBV and HCV and risk factors for HBV and HCV among (former) tatooists and piercers and individuals with multiple tattoos or piercings.
What is the attack rate of symptomatic and asymptomatic (tropical) diseases in long-term travelers.Which behavioral risk factors are of influence on the attack rates? (compliance with preventive measures, other risk behaviour)Are certain groups of…
1. To gain insight into the prevalence and incidence of HIV and other sexually transmitted infections and blood borne infections among visitors of the STI clinic in Amsterdam.2. To gain insight into risk factors and risk behaviour among visitors of…
The primary objective of this Registry is:• To assess the durability of sustained virologic response (SVR) following treatment in a Gilead-sponsored hepatitis C study.The secondary objectives of this Registry are:• To determine whether subsequent…