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Grazoprevir (MK-5172) + Elbasvir (MK-8742) for the treatment of ACUTE hepatitis C genotype 1/4. The Dutch Acute HCV in HIV Study (DAHHS-2)

The goal of this study is to document the efficacy of a shortened 8-week therapy with grazoprevir and elbasvir in patients with acute HCV genotype 1 or 4 infection.

A Long-Term Follow-Up Study of Subjects Who Participated in a Clinical Trial in which
Peginterferon Lambda 1-a (BMS-914143) was Administered for the Treatment of Chronic Hepatitis C

Recent studies demonstrate long-term durability of virologic response with pegylated alpha-interferon-based therapies. Comparable information is not yet available for Lambda or for regimens combining lambda interferons, RBV, and DAAs. In this…

HPV infections of the penis among men who have sex with men

This study's major aim is to determine whether a relation can be found between specific penile HPV types and the presence, quantity and size of flat penile lesions. Secondly, other possible determinants, such as HIV status, circumcision status…

The impact of cytotoxic T lymphocytes on the lifespan of productively infected cells in HIV infection

The primary objective of this study is to explore if (and which) HIV-specific CTL responses shorten the lifespan of productively infected cells in HIV-infected individuals. This will be accomplished by investigating the estimated life spans of…

An Open-Label Study of GS-7977+ Ribavirin with or without Peginterferon Alfa-2a in Subjects with Chronic HCV Infection who Participated in Prior Gilead HCV Studies

The primary objectives of this study are:* To determine the efficacy of GS-7977 + RBV with or without Peginterferon alfa-2a (PEG) as measured by the proportion of subjects with sustained viral response at 12 weeks after discontinuation of therapy (…

Co-infections in bronchiolitis: incidence, clinical symptoms and influence of cohortisolation

The purpose of this study was to determine the incidence and severity of co-infection in children hospitalised for bronchiolitis, when cohorting of RSV-infected patients is omitted. . Furthermore we want to elucidate general epidemiological data on…

Efficacy of 12 week boceprevir in addition to standard of care therapy consisting of peginterferon-alpha-2b and ribavirin for the treatment of acute HCV genotype 1 in HIV co-infected patients. A proof of concept feasibility clinical trial.

Document the efficacy and tolerability of 12 weeks of Boceprevir (Victrelis®) therapy in addition to standard of care (SOC) therapy consisting of weekly weight based peginterferon alfa-2b (Pegintron®) SC and ribavirin PO BID, for the treatment of…

Measurement of yellow fever vaccine efficacy; is 10 years the right point in time for revaccination?

Objectives:1) By measuring neutralising antibodies as well as immune memory in travelers vaccinatedpreviously (> 10 years ago) with yellow fever vaccine, an assessment of the duration ofvaccine induced immunity can be made.2) To provide the…

MAGNITUDE-A Phase 3 Evaluation of the Safety and Efficacy of Lambda/RBV/DCV in Treatment Naïve Subjects with Chronic HCV Infection, who have Underlying Mild or Moderate Hemophilia or Patients who are Prior Relapsers to Pegylated interferon alfa/RBV;Revised Protocol 01 Incorporates Amendment 02 and Administrative Letter 01 and 02;+ Pharmacogenetics Blood Sample Amendment Number 01 - Site Specific (version 1.0, dated 11-Sep-12)

Primary Objectives:The primary objective for this study is to evaluate the proportion of subjects who achieve SVR12 (HCV RNA < LLOQ (target not detected) at post-treatment follow-up Week 12 in subjects with GT-1b, -4 and GT-2, -3.Secondary…

A pilot study on the efficacy and pharmacokinetics of a switch from nevirapine with emtricitabine, tenofovir or lamivudine, tenofovir or lamivudine, zidovudine to rilpivirine with emtricitabine, tenofovir in virologically suppressed HIV-1 infected patients.

Primary objective:To evaluate the efficacy of a RPV based HAART in patients that switch from NVP with FTC, TDF or lamivudine (3TC), TDF or 3TC, zidovudine (ZDV) to RPV/FTC/TDF.Secondary objectives:To measure the impact (strength and duration) of NVP…

Treatment adherence in patients treated with telaprevir for a chronic hepatitis C genotype 1 infection: an observational study

Primary objective To establish the mean level of adherence to telaprevir in chronic hepatitis C patients during treatment with telaprevir, pegylated-interferon-alfa and ribavirin.Secondary objectives• To establish the mean level of adherence to…

Effect of ASV and DCV therapy on the quality of immune status in chronic HCV patients;Investigator initiated research proposal nr. AI447-108

To evaluate in detail the functionality of immune cells in blood in chronic HCV patients before, during and after treatment with ASV and DCV, in an IFN-free regimen.

A Multiple Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of MK-8408 in Subjects with Hepatitis C Infection

-To identify a safe dose of MK-8408 in HCV infected patients that mediates a 3Log10 reduction-To evaluate safety and tolerability of MK-8408 administered for 5 consecutive days-To evaluate the plasma pharmacokinetic profile of multiple oral doses of…

Role of periodontitis in accelerated ageing in HIV-infected patients

1. Determine the relationship between periodontitis and HIV-related immune activation and hypercoagulability.2. Explore the role of oral microbiota as effect modificator of the relationship between periodontitis and immune activation in HIV-infected…

An Open-Label, Single Dose, 4-Period, 4-Way Randomized Crossover Study to Evaluate the Pharmacokinetics of Preliminary Market Formulations of MK-8408 in Healthy Adult Subjects.

Primary:1. To assess the pharmacokinetic profiles following single dose administration of MK-8408 administered as a PMF1 tablet by means of AUC0-*, AUClast, AUC0-24, Cmax, C24, tmax, and t* under fed conditions, following a high fat meal. 2. To…

Identification of potential pathogens responsible for influenza-like illness in elderly in The Netherlands. Evaluation of humoral and cellular immunity against identified microorganisms

Primary: to determine the percentage of ILI attributable to influenza virus in elderly individuals * 60 years of age Secondary: to determine the relative contribution of influenza viral subtypesSecondary: to determine humoral and cellular immune…

Prevention of late presentation of an HIV infection

To determine the prevalence of HIV infection in patients presenting at the ED of the Erasmus MC, Maasstad Hospital or AMC

A Phase 2, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose Combination + Ribavirin Administered in Subjects Infected with Chronic HCV who have Advanced Liver Disease or are Post-Liver Transplant

The primary objectives of this study are:•To explore the antiviral efficacy of combination therapy with SOF/LDV FDC + RBV for12 or 24 weeks in subjects with advanced liver disease (either pre-liver transplant or notcurrently wait-listed) and post-…

Mumps virus transmission in vaccinated populations,WP 2: short-term and long-term complications of mumps-associated orchitis in vaccinated men * a prospective multicenter cohort trial

To assess short-term and long-term complications of mumps-associated orchitis in vaccinated men

TREATMENT WITH CMV PP65 SPECIFIC T CELLS GENERATED BY USE OF A CMV PP65 PROTEIN-SPANNING PEPTIDE POOL IN PATIENTS WITH CMV REACTIVATION OR CMV DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION

• To assess the feasibility, tolerability and safety of administration of donor or patient derived CMV pp65-specific T cells in patients with CMV reactivation or CMV disease after alloSCT.• To determine the presence of CMV specific T cells at…