292 results
Primary ObjectiveThe primary objective of the trial is to provide continued access to TMC278 for subjects who were randomized andtreated with TMC278 in the Phase IIb (e.g., TMC278-C204 [C204]) or Phase III trials (e.g., TMC278-TiDP6-C209[ECHO] and…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
Primary: To assess the effect of multiple oral doses of 600 mg efavirenz once daily on the PK of BMS-790052 at steady state in healthy subjects.Secondary: To assess the safety of multiple oral doses of BMS-790052 given alone and together with…
The purpose of the study is to investigate the effect of multiple oral doses of Tenofovir on how quickly and to what extent BMS-790052 is absorbed and eliminated from the body and the effect of multiple oral doses of BMS-790052 on how quickly and to…
Primary Objective: To assess the effect of multiple oral doses of atazanavir 300 mg + ritonavir 100 mg once daily on the PK of BMS-790052 at steady state in healthy subjects.Secondary Objective(s): To assess the safety of multiple oral doses of BMS-…
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
Applicability of fetal brain imaging techniques for clinical purposes.
This study will be conducted in two parts as described below:Part 1 will include subjects who participated in a Phase 1, 2, or 3 clinical study in which boceprevir was administered.Part 2 will include subjects who participated in a Phase 1, 2, or 3…
The main objective of this study is to compare the incidence of KPTD in mildly renally impaired HBV-infected persons on TDF to the incidence in patients with normal renal function. Secondary goals are to relate tenofovir plasma, intracellular and…
• to describe the epidemiological trends of dengue infections imported to Europe by returning travelers• to describe the full clinical spectrum of dengue disease imported to Europe by returning travelers• to report the phylogeny, selection pressure…
The objective of the study is to investigate the association between IL28 SNPs and the outcome of acute HCV treatment (response or non-response) in HIV-infected patients.
The main objective of this study is to assess incidence of, clinical determinants for, dose reduction in and reversibility of tenofovir associated renal insufficiency and KPTD.Secondary objectives are to assess kidney tubular function in patients…
The aim of this study is to determine the clinical benefit of effective antiviral treatment in patients with advanced fibrosis due to chronic hepatitis C infection.
The aim of the research is to gain more knowledge on the influence upper respiratory infections on the course of pregnancies.
To assess symptomatic and asymptomatic attack rate through the analysis of specific (IgG) antibody responses prior to, and in response to mumps virus infection; Secondary: to estimate a serological correlate for immune protection against symptomatic…
Primary objective: * Examine the safety and tolerability, both local and general, of ProCervix Solution (escalating doses) and ProCervix Powder in women infected by HPV 16 and/or 18 with normal cytology from Week 0 to Week 10. Secondary objectives…
The primary aim of our study is to link stated preferences of parents of newborn children for hepatitis B vaccination to actual vaccination behaviour. The secondary objective is to determine the external validity of the Discrete Choice Experiment as…
The purpose of this long-term follow-up (LTFU) study (ZOSTER-024) is to evaluate the cell-mediated and humoral immune responses of subjects who previously participated in study ZOSTER-003 and who were in the group receiving 2 doses of 50µg gE/AS01B…
Primary: to determine the percentage of ILI attributable to influenza virus in elderly individuals >= 60 years of age Secondary: to determine the relative contribution of influenza viral subtypesSecondary: to determine humoral immune response…