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Detection of schistosoma CAA in travellers after high-risk water contact

Primary objective: to assess the UCP-LF CAA test in travellers with high-risk water contact as compared to routine diagnostics

Gene expression in sepsis and sterile sirs in pediatric patients after cardiac surgery

To differentiate between gene expression in sepsis and sterile sirs.

Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center

Primary objective:To establish four healthy donors for future CHHI studies

Establishing a Female-only Controlled Human Schistosoma mansoni Infection Model: a safety and dose finding study (CoHSI2)

Primary Objective: - To investigate the safety, tolerability and attack rate of female Schistosoma mansoni cercariae in healthy Schistosome-naïve volunteers Exploratory Objectives: - To investigate the kinetics of circulating anodic antigen (CAA)…

Maintaining Controlled Human Hookworm Infection Model studies at Leiden University Medical Center

Primary objectives: • To establish two hookworm-infected donors to set up the controlled human hookworm infection model in Gabon • To study early-phase immune responses to hookworm exposure during the first four weeks after challengeExploratory…

Assessment of infection activity in travelers and migrants diagnosed with
chronic schistosomiasis: a multicentric prospective cohort study

To determine the proportion of travelers and migrants diagnosed with chronic schistosomiasis as per each centre*s routine assessment, who have active infection at presentation (as assessed and classified by composite reference standards integrating…

Establishing a Single-sex Controlled Human Schistosoma mansoni Infection Model: safety and dose finding

Primary objective: To investigate the safety, tolerability and infectivity of male Schistosoma mansoni cercariae in healthy Schistosoma-naïve volunteers. Exploratory objectives: To investigate the kinetics of controlled infection with male…