32 results
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
The primary aim of this project is to discover new cellular (non-invasive) biomarkers for the diagnosis and monitoring of immune-mediated liver diseases. Secondly we aim to effectively differentiate AIH from DILI and NAFL from NASH.
In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
Objective: Primary objectives: To screen TCR/BCR repertoires in patients with primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and IgG4-associated cholangitis (IAC).Secondary objectives: To determine the influence of disease…
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
To evaluate the prevalence of gastrointestinal ischemia in patients with acute and chronic non-cirrhotic, non-malignant PVT.
Our principal aim is to assess the effects of phlebotomy on aortic augmentation (AIx) and central BP in supine position and after standing; second, to assess the effects of counter maneuvers (leg crossing and thigh compression) on aortic…
The aim of this study is to investigate the T cell immune system in relation to viral kinetics in acute HBV infection in order to obtain more insight into mechanisms of failure of viral control and development of chronic HBV infection, and to…
The aim of this study is to investigate the effect of ATP8B1 carrier on hearing in human.
To determine if LA is a familial disease. To identify germline mutations in HNF-1 alpha, ß-catenin and CYP1B1 genes in LA patients. To screen first degree relatives of patients diagnosed with liver adenomatosis for the presence of liver adenomas and…
To determine the 1 year sustainability of the effects of a lifestyle intervention on NAFLD in severely obese children and determine the relation between long term changes in liver steatosis and other clinical and biochemical parameters. Finally, to…
Primary aimTo evaluate the effects of peginterferon and ribavirin therapy on the immune response in chronic HCV genotype 1 patients before, during and after treatment.Secondary aims1. To determine if differential modulation of Treg activity or DC…
A proof-of-principle study to test whether an environmental factor, i.e. here IFNα treatment, induces epigenetic alterations of certain genes in blood lymphocytes and whether these alterations correlate with the severity of psychiatric symptoms, i.e…
- Is there a correlation between liver fat content and inflammation in patients with or without STNFR-2 polymorphisms (-1031C, -863A)?- What is the correlation between weight reduction and decrease of hepatic steatosis?- What is the correlation…
Primary objective: to investigate the incidence of IAC in patients resected for presumed PHC.Secundary objectives:- Evaluation of the diagnostic accuracy of histological criteria for IAC compared to IgG4 qPCR test- Evaluation of disease activity by…
To gain insight in the metabolic, microbiota and immunologic changes after bariatric surgery that drive NAFLD/NASH and weightless resulting in subsequent conversion of malign to benign obesity.
We aim to identify hepatic, plasma, genetic and gutmicrobial markers that, alone or in combination, enable detection and monitoring of disease progression from NAFLD to NASH and subsequent progression from NASH to cirrhosis.
1. The primary objective of the European NAFLD Registry observational study is to assemble a cohort of well-characterised patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and to collect associated clinical information, biological samples and…
The primary objective of this study is to examine to what extent hepatic glycogen is decreased after a prolonged overnight fast in healthy volunteers with a normal weight and low liver fat percentage.