34 results
Optimizing (breathing) techniques for radiotherapy of esophageal and lung carcinomas; a pilot study.
Primary objective: To determine the optimal breathing technique to minimize the dose to the heart of radiotherapy for esophageal and lung cancer using current photon techniques, without compromising the dose to the lungs. Secondary Objectives: 1. To…
1. To confirm established and identify new risk factors for colorectal cancer in a prospective cohort of IBD patients undergoing regular surveillance. Dysplasia or colorectal cancer will be the primary outcome.2. To provide evidence that mucosal…
The main objective of this study is to determine the most suitable diagnostic test to identify cardiopulmonary (dys)function in EC survivors treated with neo-CRT followed by surgical resection. Furthermore, we want to estimate the difference in…
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We would like to conduct a RCT to confirm the hernia prevention effect of a mesh, however in a slightly different position, with a different mesh and with all types of stomas. In addition, we want to measure the possible benefit in terms of quality…
Primary: • Assess effect of AN-PEP on gluten epitope degradation in the duodenumSecondary: • Assess effect of AN-PEP on gluten epitope degradation in the stomach• Assess effect of meal caloric content on the efficacy of AN-PEP on gluten epitope…
The global aim of the current project is to demonstrate that colorectal cancer (CRC) patients can benefit from neo-antigen-targeted therapies.
The primary objective is to evaluate the safety and efficacy of anakinra in patients with multiple myeloma receiving high-dose melphalan (HDM) in the preparation for an autologous hematopoietic stem cell transplantation (SCT). Secondary objectives…
Primary objectivesTo study if LcS can colonize the esophagus of BE patients.To study the effect of LcS colonization on the Gr+ (except for LcS)/ Gr- bacterial ratio of the esophagus.Secondary objectivesTo quantify the number of specific pathogenic…
The main objective of this study is to find a correlation between the rise in NT pro BNP level and the radiation dose given to the heart.
The aim of this study is to investigate if curcumin is detectable when subjects use curcumin supplements in daily life.
Developing an evidence-based guideline for the diagnosis and surgical treatment of children with severe gastro-esophageal reflux disease.
The primary objective of this second phase study is to estimate the occurrence of anastomotic leakage when the C-seal is used.Secondary objectives are:* Feasibility of applying the C-seal, especially considering the improved attachement to the…
The aims of this study are: 1) To prospectively determine the incidence of HPS/polyps and CRC in first-degree relatives of patients with HPS so as to define whether screening of this group is justified.2) To assess the proportion of individuals that…
To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.
To assess in a cohort of patients with established FAP:1 The efficacy of MPA in terms of reduction of number of colonic polyps, by means of Endoscopic Appearance of Polyposis (EAP) index.2 The effect on histological parameters and biological…
The primary objective of this clinical survey is to investigate the difference in morbidity and mortality after elective abdominal surgery for colon or rectal carcinoma in different age groups (55-75 years and older than 75 years).and to determine…
At first, to describe the UC, CD, and IBS outpatient population in the Netherlands. Secondly to gain insight into disease and treatment characteristics, as well as lifestyle and clinical factors identified as potential risk factors of a UC, CD, and…
The objective of this pilot study is to investigate wether:- Increased Hb levels prior to the operation can prevent blood transfusions preoperative, blood transfusions have a negative effect on the survival of cancer patients- Treatment with…
The primary objective is the safety and feasibility of CEA/frameshift derived neopeptide loaded DC in patient with MSI-positive colorectal cancer and persons who are known to be carrier of a germline MMR-gene mutation with no signs of disease yet.…