18 results
To explore the extent of inter- and intrafraction anatomical changes of the tumour and surrounding normal tissues, throughout the full course of treatment, and to subsequently assess the impact of these changes on the nominal planned dose. This…
To address the hypothesis that a potato derived protease inhibitor cream significantly limits perianal dermatitis in patients after colorectal surgery.
A new surgical device for the creation of compression anastomoses, the ColonRing*, which is nickel- titanium based, has been introduced. Safety and efficacy of the device have been established in previous clinical studies and the device has been…
In daily practice there are many treatment modalities for hemorrhoids available. Since many years the rubberband ligation is widly used. Recently there are also positive results reported of the artery ligation procedure. This research aims to…
The primary efficacy variable is if the TachoSil application was feasible. A feasible application implies that the entire TachoSil adhere, TachoSil covers at least 1 cm beyond the margins of the anastomosis line and if more TachoSil sponges are used…
With this study we aim to determine the feasibility of Smooth Seton placement in patients with perianal fistulas
To assess efficacy of INCMGA00012 in terms of the ORR in participants with locally advanced or metastatic SCAC who have progressed after platinum-based chemotherapy.
The objective of this study is to assess the long-term safety of linaclotide in pediatric participants with FC (total exposure with linaclotide for 24 weeks) or IBS-C (total exposure with linaclotide for 52 weeks) who have completed study…
The primary objective of this RCT is to compare the effectiveness of RBL, sutured mucopexy and haemorrhoidectomy regarding recurrence and patient-reported symptoms for recurrent grade 2 and 3 HD after at least 2 previous RBL treatments. Secondary…
This study investigates the two most commonly performed surgical procedures for treatment of grade III hemorrhoids. It aims to identify the best surgical treatment for this patient group considering quality of life.. Other outcomes measured are…
With this pilot study we aim to determine the feasibility and efficacy of the novel catheter set, the Semiflex Dome Catheter System, for vacuum therapy of perianal abscesses/sinuses and fistulas. The pilot study will consist of 2 parts. First, 10…
The primary objective of this exploratory proof of concept clinical investigation is to confirm bulb catheter*s performance in adults already using Navina Smart.The secondary objectives and endpoints are to evaluate bowel emptying performance of…
With this study we hope to improve the closure rate of perianal Crohn*s fistulas.
This study has been transitioned to CTIS with ID 2023-503973-39-00 check the CTIS register for the current data. To evaluate the efficacy of darvadstrocel in combined remission at Week 24 for the treatment of complex perianal fistula in pediatric…
The main objective of this study is to establish the efficacy of *pit picking with laser therapy* versus *pit picking alone* on both short and long-term outcomes.
The aim of this study is to determine feasibility of perineal reconstruction using a gluteal subcutaneous transposition flap (Luna flap) after eAPR for rectal cancer.
Our hypothesis is that treatment of peri-anal fistula with laser ablation is associated with equal closure rates compared to current therapies. As secundairy outcome, quality of life, postoperative pain and incontinence will be assessed. The primary…
With this study we aim to determine the feasibility of SuperSeton placement in patients with perianal fistulas.