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Epithelial Ion Transport Defects in Pancreatitis: establishment of an organoid model

Primary: To evaluate the ability to culture PDEC organoids from pancreatic duct biopsies. Secondary: (i) To evaluate ion transport in PDEC organoids derived from pancreatitis patients. (ii) To evaluate the ability of duodenal organoids to mimic ion…

Prospective Multicenter Microbiota Study for Evaluation and Monitoring of Severe Acute Pancreatitis

1) To establish associations between microbiome profiles and disease severity in patients with acute pancreatitis. 2) To establish associations between specific microbial shifts and infectious complications in the subgroup of patients with…

Next generation sequencing in patients with pancreatic ductal adenocarcinoma (PAN-NGS).
A nationwide prospective, translational cohort study.

To determine the prevalence of actionable genetic alterations in PDAC patients <= 60 years old.