121 results
The aim of the study is to assess the efficacy and safety of the self-sizing RFA ballon for eradication of Barrett's mucosa with low-grade, high-grade and early neoplasia
The study will collect data related to symptoms of recurrent biliary stent obstruction requiring reintervention, adverse events, and a variety of important secondary endpoints including technical success and time to symptomatic recurrent biliary…
To evaluate the feasibility and accuracy of sentinel node navigation surgery in patients with early esophageal carcinoma.
Determine the efficacy of combination gemcitabine and docetaxel chemotherapy in the treatment of metastatic colorectal cancer with CHFR and/or MSI phenotype
To determine safety and technical feasibility of stereotactic radiotherapy for locally advanced and locally recurrent pancreatic carcinoma.
The primary objective is to describe the functional outcome of patients that choose for organ saving treatment.
To assess the safety and feasibility of curative esophagectomy combined with three field lymphadenectomy after chemo-radiation in Western patients with resectable thoracic esophageal carcinoma and cervical lymph node metastases in level III and/ or…
Evaluate the safety and tolerability of AMG 211 in subjects with advanced gastrointestinal (GI) adenocarcinomas Determine the maximum tolerated dose (MTD) and/or biologically active dose
The primary objective of this study is to evaluate the safety and performance of the CryoBalloon Ablation Systems (Full and Swipe) for the ablation of human esophageal epithelium.
The primary objective of this feasibility/pilot study is to find the correct scanning protocol to assess 5FU drug trapping in colorectal cancer liver metastases using 7T MRS (phase 1). Secondary objectives will be assessed during phase 2 of this…
The primary objective of this study is to evaluate the long-term safety and tolerability of orally administered telotristat etiprate.The secondary objective is to evaluate changes in patients* quality of life (QOL) through week 84.
Primary: Progression free survival.Secondary: Toxicity, overall survival, response rate, duration of response, translational research.
This study aims at developing a novel strategy to optimise the treatment of oesophageal adenocarcinoma and gastro-oesophageal junctional tumors with curative intent. To improve the outcome of patients with this disease we hypothesize that the…
This study aims to determine whether early start of oral intake in patients that underwent an esophagectomy is feasible and safe.
Primary:- To determine the MTD and/or a recommended phase II dose (RP2D) of BYL719 when administered orally in combination with imatinib 400 mg q.d.Secondary:- Assess the safety and tolerability profile of imatinib and BYL719 administered in…
The aim of the clinical trial is to evaluate Hybrid-APC as a thermal ablation therapy for the treatment of BE following preceded endoscopic resection (ER) or as a primary therapy for neoplasia that are initially not detectable using high resolution…
This is a feasibility study of the Balloon-based Focal Cryoablation System to assess safety and performance in patients with a Barretts esophagus
To evaluate the feasibility of thoracolaparoscopic lymph node dissection of lymph nodes involved in the drainage of the esophagus in patients with esophageal carcinoma
The objective of this study is to investigate the amount of clinically relevant complications (defined by Clavien-Dindo score 3 or higher) caused by IRE in patients with locally advanced, non-resectable, non-metastasized, pancreatic cancer.
This is a feasibility study of the System to assess safety and performance in patients scheduled to undergo esophagectomy.