111 results
The aim of this present diagnostic study is to determine the accuracy by which we can detect residual disease after neoadjuvant chemoradiotherapy.
To evaluate the detection ctDNA in patients with PC of colorectal origin undergoing cytoreductive surgery and HIPEC at time of diagnosis in a feasibility trial This study is considered feasible:1. If in at least 70% of the patients ctDNA status…
Currently, only few publications exist which describe MRI for esophageal cancer. Therefore, the objective of the study is to develop a MRI protocol for imaging of this organ. The research will particularly be focussed on functional MRI. Those scans…
To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.
Part 1 1. Determine if accumulation of the fluorescent tracer bevacizumab-800CW can be detected for identification of pancreatic cancer tissue during surgery.2. Identify two doses of conjugate that provide the best visualization of tumor tissue…
To evaluate the sensitivity of second-look endoscopic biopsies from the polypectomy site for residual adenocarcinoma in the surgical resection specimen.To register patients in whom exclusion criteria exist, in order to prospectively evaluate the…
To evaluate whether blood CC12gene expression defines disease status (Stage I-IV, stable or progressive) and whether the blood CC12gene expression predicts response to therapeutic intervention.
1. Evaluate the feasibility of ESS for detection of field cancerization in BE patients. 2. Investigate the biological background of field cancerization by studying: a) (ultra)structural changes in the tissue and b) genetic abnormalities and clonal…
Primary Objective: Visualization and quantification of tumor hypoxia with [18F] HX4 PET imagingSecondary Objectives: - Correlation of [18F] HX4 with local tumor recurrence and survival- Correlation of hypoxia imaging with blood hypoxia markers -…
The aim of this study is to compare the image quality, diagnostic confidence and patient discomfort when using either positive (50 ml Télébrix Gastro + 950 ml water ) or negative 1000 ml water only in outpatients undergoing a contrast-enhanced…
Primary objective: To study the faesibility of SLNM in patients with histological proven colon cancer using NIR-laparoscopy.Secondary objectives: To study the incidence of micrometastasis with the use of ICG and RT-PCRTo determine the number of…
The primary objectives are to determine the diagnostic performance of gadofosveset-enhanced T1-weighted MR imaging for the discrimination between pN0 and pN+ patients for both primary staging and restaging after chemoradiotherapy and to determine…
In patients undergoing surveillance endoscopy for Barrett's oesophagus or work-up and treatment for early neoplasia in Barrett's oesophagus we will evaluate the N-Vision pVLE system for the following items: 1) Correlating the VLE images…
The primary objective of this pilot intervention study is to determine the sensitivity of the fluorescent tracer bevacizumab-IRDye800CW using a flexible NIR fluorescence endoscope in identifying (pre)malignant esophageal lesions during endoscopy.…
1. The primary aim of the proposed research is to compare the value of current best available imaging method (PET-CT) with recently evolved functional imaging with DWI-MRI alone or in combination with PET/CT in determining response to neo-adjuvant…
The aim of this study is to investigate the feasibility of VLE to detect the presence of glandular structures under the NSE after RFA and direct correlation of VLE images with histopathology.
The objective of this explorative study is to assess the value of anatomical and functional magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography and computed tomography (PET-CT) in the evaluation of treatment…
To investigate the feasibility of imaging and measuring enhancement of colorectal cancers and polyps using iodine mapping after acquiring dual energy abdominal CT scan with intravenous iodine contrast in patients without bowel preparation.
1. to investigate the WavSTAT optical biopsy system by collecting fluorescence spectra of non-dysplastic and dysplastic Barrett mucosa and correlate these to the histology. The integrated optical/physical biopsy forceps will ensure spot-on…
The study is designed to assess the diagnostic value of contrast agents on endosonographic images during the evaluation of focal pancreatic lesions.