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Diagnostic yield of screening colonoscopy in Hodgkin lymphoma survivors

The first objective is to assess the value of colonoscopy screening in HL survivors. The second objectives are to evaluate the neoplasia characteristics and its relation to radiotherapy and chemotherapy, in order to improve the understanding of the…

Non invasive imaging of tumor hypoxia with [18F]HX4 Positron-Emission-Tomography (PET): A phase II trial

Primary Objective: Visualization and quantification of tumor hypoxia with [18F] HX4 PET imagingSecondary Objectives: - Correlation of [18F] HX4 with local tumor recurrence and survival- Correlation of hypoxia imaging with blood hypoxia markers -…

A Multicenter, Long-term Extension Study to Further Evaluate the Safety and Tolerability of Telotristat Etiprate (LX1606)

The primary objective of this study is to evaluate the long-term safety and tolerability of orally administered telotristat etiprate.The secondary objective is to evaluate changes in patients* quality of life (QOL) through week 84.

Detection of (sub) clinical toxicity in irradiated vs. non-irradiated surgically treated esophageal cancer patients: a pilot study.

The main objective of this study is to determine the most suitable diagnostic test to identify cardiopulmonary (dys)function in EC survivors treated with neo-CRT followed by surgical resection. Furthermore, we want to estimate the difference in…

A feasibility study comparing two strategies of oral contrast in patients undergoing contrast-enhanced abdominal CT: 50 ml Télébrix Gastro + 950 ml water vs 1000 ml water only.

The aim of this study is to compare the image quality, diagnostic confidence and patient discomfort when using either positive (50 ml Télébrix Gastro + 950 ml water ) or negative 1000 ml water only in outpatients undergoing a contrast-enhanced…

In vivo study to determine the efficacy of sentinel node mapping in patients with colon carcinoma using near-infrared laparoscopy after submucosal injection

Primary objective: To study the faesibility of SLNM in patients with histological proven colon cancer using NIR-laparoscopy.Secondary objectives: To study the incidence of micrometastasis with the use of ICG and RT-PCRTo determine the number of…

The predictive value of cytokines on response to preoperative chemoradiotherapy in patients with rectal cancer.

Predictive factors are needed to discriminate chemoradiotherapy responders from non-responders and to individualize the treatment regime. Various cytokines play a role in processes affecting tumour growth and metastasis. Furthermore, cytokines might…

Phase II Study of Docetaxel, Oxaliplatin, Capecitabine with Bevacizumab and Trastuzumab in case of human epidermal growth factor receptor 2 (HER2)-positivity in Patients with Locally Advanced or Metastatic Gastric Cancer or Adenocarcinoma of the Gastro-oesophageal Junction (B-DOCT study)

Primary: Progression free survival.Secondary: Toxicity, overall survival, response rate, duration of response, translational research.

Multi-Modality Treatment of Resectable Oesophageal Adenocarcinoma using Peri-operative Chemotherapy with additional Pre-operative Combined Radiotherapy and Cetuximab

This study aims at developing a novel strategy to optimise the treatment of oesophageal adenocarcinoma and gastro-oesophageal junctional tumors with curative intent. To improve the outcome of patients with this disease we hypothesize that the…

Nutritional Route In Esophageal Resection trial

This study aims to determine whether early start of oral intake in patients that underwent an esophagectomy is feasible and safe.

Macroscopic and microscopic changes of a locally advanced rectal tumour during radiotherapy: assessment using anatomical, functional and cinematic MRI.

The purpose of this pilot study is twofold: - evaluation of the tumour movement and regression during and short after long course pre-operative therapy for locally advanced rectal cancer in order to develop an integrated or sequential dose…

A dose-finding phase Ib multicenter study of imatinib in combination with the oral phosphatidyl-inositol 3-kinase (PI3K) inhibitor BYL719 in patients with gastrointestinal stromal tumor (GIST) who failed prior therapy with imatinib and sunitinib

Primary:- To determine the MTD and/or a recommended phase II dose (RP2D) of BYL719 when administered orally in combination with imatinib 400 mg q.d.Secondary:- Assess the safety and tolerability profile of imatinib and BYL719 administered in…

Hybrid Argon Plasma Coagulation (Hybrid-APC)
for the treatment of Barrett*s esophagus with Low-Grade, High-Grade Intraepithelial Neoplasia or after Endoscopic Resection for Early Neoplasia

The aim of the clinical trial is to evaluate Hybrid-APC as a thermal ablation therapy for the treatment of BE following preceded endoscopic resection (ER) or as a primary therapy for neoplasia that are initially not detectable using high resolution…

Evaluation of Balloon-based Focal Cryoablation of Human Esophageal Epithelium

This is a feasibility study of the Balloon-based Focal Cryoablation System to assess safety and performance in patients with a Barretts esophagus

Diagnostic value of novel MR imaging techniques for the primary staging and restaging of rectal cancer

The primary objectives are to determine the diagnostic performance of gadofosveset-enhanced T1-weighted MR imaging for the discrimination between pN0 and pN+ patients for both primary staging and restaging after chemoradiotherapy and to determine…

ThORAcolaparoscopic disseCtion of Lymph nodes involved in the drainage of the Esophagus: the ORACLE study

To evaluate the feasibility of thoracolaparoscopic lymph node dissection of lymph nodes involved in the drainage of the esophagus in patients with esophageal carcinoma

Irreversible electroporation treatment in patients with pancreatic locally advanced adenocarcinoma

The objective of this study is to investigate the amount of clinically relevant complications (defined by Clavien-Dindo score 3 or higher) caused by IRE in patients with locally advanced, non-resectable, non-metastasized, pancreatic cancer.

A Comparison of Volumetric Laser Endomicroscopy (VLE) and Endoscopic Mucosal Resection (EMR) in Patients with Barrett*s Dysplasia or Intramucosal Adenocarcinoma

In patients undergoing surveillance endoscopy for Barrett's oesophagus or work-up and treatment for early neoplasia in Barrett's oesophagus we will evaluate the N-Vision pVLE system for the following items: 1) Correlating the VLE images…

A pilot intervention study for the use of VEGF-targeted Fluorescence Near-Infrared (NIR) Endoscopy in (pre)malignant Esophageal Lesions

The primary objective of this pilot intervention study is to determine the sensitivity of the fluorescent tracer bevacizumab-IRDye800CW using a flexible NIR fluorescence endoscope in identifying (pre)malignant esophageal lesions during endoscopy.…

Unraveling the Genetic Background of Colorectal Cancer in Adolescents and Young Adults.

To unravel the genetic makeup of colorectal cancer (CRC) in adolescents and young adults (AYAs) in order to improve genetic counseling, surveillance and, ultimately, treatment and disease outcome.