286 results
To investigate the feasibility and safety of preoperative stereotactic radiotherapy of 4cm pancreas in patients undergoing pancreatoduodenectomy at high risk of developing postoperative pancreatic fistula (>25%).
The aim of the current study is to assess the feasibility, safety and efficacy of the Steam ablation System for eradication of short segment BE.
The primary objective of this study is to determine the accuracy of the application of stereotactic navigation combined with 3D MRI topography during oncologic resection for primary locally advanced rectal cancer in which the tumor is grown in or…
Primary Objective: To further develop and evaluate a personalised patient-centred surveillance programme including a feedback platform for patients after curative treatment for CRC in terms of health-related quality of life (HRQoL).The goal is for…
The primary objective of the current protocol is the diagnostic value of a gastroscopy to detect gastric (pre)-neoplastic conditions in patients who need a colonoscopy as part of their clinical follow-up either after a positive screening test for…
Evaluation of IORT accuracy and effectiveness during rectal cancer surgery by determining the exact position and direction of the IORT beam through the use of an intra-operative electromagnetic image-guided navigation system.
We aim to confirm that Maastro endoluminal HDR contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in patients with rectal cancer.
Primary• To evaluate the safety and tolerability of AMG 199 in adult subjects• To determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) Secondary• To characterize the PK of AMG 199 • To evaluate preliminary anti-tumor…
The primary objective of the study is to determine the technical feasibility of ctDNA detection in small volumes of capillary blood. This will be investigated through determining the agreement between ctDNA measurements in venous (standard blood…
The main purpose is to investigate the safety, pharmacokinetics and feasibility of ONM-100 as an intra-operative optical tracer to detect tumors and metastatic lymph nodes in solid cancers. Moreover, the study will investigate the optimal dose of…
This study is designed to assess the feasibility of NIRF with ICG during open or minimal invasive esophagectomy in order to assess the gastric conduit perfusion.
To evaluate the utility of the WATS system, as a potential substitute for the random sampling method that is currently recommended as an adjunct to targeted biopsy
Until recently, the field of anti-tumor immunology has focussed on the role of T lymphocytes. Recently, however, the group of prof. H. Spits and dr. T. Beaumont developed an in vitro methodology to grow human, monoclonal, B cell receptor positive…
The primary objective of this study is to investigate the association between changes of lean body mass and overall grade 2-4 toxicity during adjuvant chemotherapy in colon (or rectal) cancer patients.
The goal of this pilot study is to calculate the sensitivity and specificity for discriminating tumour and benign tissues in vivo in colorectal cancer patients based on optical spectroscopy measurements. The secondary goal of this study is to…
The pilot study will focus completely on testing of the quality of the CCE procedure as intended in the screening trial. The main study parameters are feasibility and logistical shortcomings, efficacy of bowel preparation and understandability of…
1.We seek a better understanding of the mechanism of response / non-response to the above treatment in patients with esophageal carcinoma.2.To investigate whether there is a correlation between the CSC percentage and outcome in esophageal cancer…
Establishment of an image-guided brachytherapy procedure that is feasible for a multicenter randomized trial
1.The main objective of this study is to explore and clarify the preferences, barriers and facilitators for pre-operative exercise participation for elderly treated for colorectal cancer and their social network. 2. To identify the barriers and…
The global aim of this project is to determine the immunophenotype-genotype interactions of PC. The novel insights in the molecular genomic and immunological profile of the tumor tissue and metastases are expected to help determine the immune…