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Sentinel node Navigation surgery in early esophageal Adenocarcinoma Patients: the SNAP-II study

To evaluate the feasibility, accuracy and safety of sentinel node navigation surgery (scintigraphy combined with indocyanin green and near-infrared technology) in patients with early esophageal carcinoma.

Cytoreductive surgery and Intraperitoneal chemotherapy and for Stomach CAncer: a feasibility study

To assess the safety and feasibility of HIPEC and CS in Western patients with peritoneal metastases of gastric cancer, in terms of morbidity and mortality. Secondary objective is to determine the effect on survival and recurrence.

An open label phase II study to evaluate the efficacy and safety of PDR001 in patients with well-differentiated advanced or metastatic non-functional neuroendocrine tumors of pancreatic, gastrointestinal (GI), or thoracic origin or poorly-differentiated gasteroenteropancreatic neuroendocrine carcinoma (GEP-NEC) who have progressed on prior treatment (CPDR001E2201)

Primary: To estimate the antitumor activity (assessed as overall response rate) of PDR001 as a single agent in patients with non-functional neuro-endocrine tumors (NET).Secondary: To estimate efficacy (duration of response) of PDR001. Safety and…

Repeated magnetic resonance imaging in esophageal cancer for adaptive radiation treatment planning during chemoradiotherapy.

Primary objective:- To develop a patient-specific adaptive radiotherapy planning strategy using MRI with more precise target coverage and critical organ sparing by safely reducing treatment margins for resectable esophageal cancer irradiation.…

LoCAlly advanced and recurrent Rectal cancer NAVigationAL surgery 2.0

Within the framework of the CARNAVAL 2.0 project, this technique is applied to a larger group of 30 patients by multiple surgeons. The primary goal of the study is to determine the oncologic resection rate with a tumour-clear resection margin and…

Adaptive anastomosis for anterior resection in sigmoid and proximal rectal cancer or premalignant lesions: a multicentre non-randomised clinical effectiveness trial (ADAPT)

The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…