286 results
Study phase 1: In patients with BO undergoing work-up endoscopy for early neoplasia, we aim to develop a classification to evaluate fluorescence spectroscopy of neoplastic and non-neoplastic lesions in Barrett epithelium, as used in phase 2.Study…
The primary objective of the study is to prospectively determine whether fluoropyrimidine-induced toxicity is preventable by dose adjustment prior to start of the first administration based on the polymorphic status of the DPYD*2A polymorphism in…
1. Study the overall miss rate of polyps detected with the third eye retroscope compared to standard colonoscopy.2. Study the overall miss rate of adenoma detected with the third eye retroscope compared to standard colonoscopy.3. Analyze the time…
To evaluate the feasibility to assess treatment response on radiochemotherapy for locally advanced rectal cancer by repeated anatomical and functional MRI and FDG-PET.
To assess in a cohort of patients with established FAP:1 The efficacy of MPA in terms of reduction of number of colonic polyps, by means of Endoscopic Appearance of Polyposis (EAP) index.2 The effect on histological parameters and biological…
Is het possible to determine the presence of disseminated tumor cells in blood in patients with colonic cancer who are operated upon laparoscopiccaly?
This study investigates the feasibility role of neoadjuvant chemotherapy, consisting of docetaxel (Taxotere), cisplatin and capecitabine (Xeloda) (TCX), and protocolized surgery in localized and/or locally advanced resectable gastric cancer (D1extra…
The aim is to study safety and activity of nelfinavir, added to standard chemoradiotherapy (26x1.8 Gy and capecitabine 825 mg/m2 BID) in patients with locally advanced rectal cancer. Furthermore analysis of the effect of nelfinavir combined with…
In patients with BO undergoing surveillance or work-up endoscopy for early neoplasia, we aim to evaluate if EQMI, consisting of ETMI combined with pCLE, increases the accurary of detecting early neoplasia (study phase 1). In addition, we aim to…
The aim of this randomized controlled study is to compare two surveillance strategies with respect to their accuracy in colonoscopic surveillance in IBD patients.
Feasibility study: The potential use of intraoperative, ICG based, fluorescence imaging of LN*s during CRC lymphadenectomy.
Primary objective: to investigate the day-to-day shape variation of the CTV in rectal cancer patients in order to determine adequate PTV margins for radiotherapy treatment.Secondary objectives: to investigate the influence of bladder and rectal…
The primary objective of the study is assessment of the dose limiting toxicity (DLT) and maximal tolerated dose (MTD) of docetaxel, oxaliplatin and capecitabine given in combination in patients with advanced cancer of the stomach or the gastro-…
The aim of this study is to investigate whether DWIBS is appropriate for colorectal cancer screening.
Purpose: To evaluate the feasibility and efficacy of a combination of preoperative chemoradiation of Paclitaxel 50mg/m2 and Carboplatin AUC 2 given intravenously on day 1, 8,15, 22 and 29 in combination with 45 Gy (fractions of 1.8Gy) for locally…
The primary objective of this study is to evaluate the prevalence and risk of advanced colorectal neoplasia in asymptomatic non-PSC post-liver transplant recipients compared to an age- and sex matched general population.Secondary Objectives- To…
To investigate the diagnostic accuracy and burden of MR colonography at 3.0 Tesla, using limited bowel preparation and CO2 for colonic distension.
The primary objective of this second phase study is to estimate the occurrence of anastomotic leakage when the C-seal is used.Secondary objectives are:* Feasibility of applying the C-seal, especially considering the improved attachement to the…
Primary: Evaluate the ergonomics and function of the imaging system - the NIRF imaging system should not interfere with the standard esophagus resection and lymphadenectomy procedure by the surgeon while detection of indocyanine green (ICG) takes…