286 results
To compare the yield of autofluorescence guided targeted biopsy versus four-quadrant random biopsy in the evaluation of patients with known occult neoplastic lesions in Barrett*s Esophagus.
The aims of the study are: 1) to characterize the mucosal morphology and vascular pattern of neoplastic and non neoplastic mucosa by NBI and standard White Light Endoscopy (WLE) in the upper gastrointestinal tract; 2) to compare the accuracy of NBI…
To evaluate the effectiveness of optimization of CEA measurements after curative resection of stage II, III and IV colorectal carcinoma. The short-term effectiveness will be quantified in percentage of patients that are eligible for curative…
To determine the additional value of NBI-ME to conventional endoscopy in the surveillance of patients with intestinal metaplasia and dysplasia, i.e. to evaluate whether the use of NBI-ME is superior to conventional endoscopy in the detection of…
To recognize the distribution pattern of 111In-bevacizumab in patients who do not show response on treatment with bevacizumab. The ultimate goal is to identify and select patients who can be successfully treated.
-To determine the feasibility and the maximum tolerated radiation dose in HDRBT of the rectum after EBRT in rectal cancer patients who are unfit for surgery or refuse surgery-To determine the incidence and severity of acute and late toxicity of EBRT…
The aims of this study are to assess the additional value of NBI in comparison to white-light endoscopy (WLE) for the detection and classification of HPs, SAs, MPs and adenomas in patients with HPS.
The primary objective of this clinical survey is to investigate the difference in morbidity and mortality after elective abdominal surgery for colon or rectal carcinoma in different age groups (55-75 years and older than 75 years).and to determine…
The purpose of this project is to evaluate the combination of ER using the multi-band mucosectomy technique and RFA (HALO360/HALO90) for treatment of Barrett*s esophagus with HGD or early cancer. This will be a multi-centre European study including…
To compare respiratory waveforms generated using reflective markers located on the upper abdominal wall (the currently used Varian RPM system) with either magnetic sensors, belt sensors or both placed on the chest wall and/or upper abdomen. The…
The main objective of this study is to find a correlation between the rise in NT pro BNP level and the radiation dose given to the heart.
Primary Objectives:1. To compare the protein synthesis of pancreatic, liver, intestinal, fat and muscle tissue and leukocytes in cachectic patients.2. To compare pancreatic malignancy protein synthesis with the protein synthesis in normal pancreatic…
The primary objective of this study is to determine the sensitivity of the marker bevacizumab-IRDye800CW using innovative NIR fluorescence endoscopy (visualizing with wide-field endoscopy, measuring with MDSFR/SFF spectroscopy and optionally…
This pilot study will evaluate the feasibility of endoscopic guided placement of gold markers in rectal cancer patients including:- Technical success of fiducial marker placement by (EUS guided) endoscopy- Visibility of fiducial markers on MRI and…
The aim of this study is to evaluate the endoscopic removal of early Barrett*s neoplasia and early squamous esophageal neoplasia with assistance of a modified esophageal overtube, using standard ESD techniques
The feasibility of preparing untreated esophageal adenocarcinoma endoscopic biopsies towards DNA/RNA samples suitable for next-generation sequencing.
Primary Objective: The primary objective is to study the potential role of F. nucleatum in the development of colorectal cancer by isolating F. nucleatum strains from large adenoma biopsies, healthy colorectal tissue and matching stool and saliva…
Primary objective:To gather information on the feasibility of a prospective, international multicenter study in which, on the basis of biomarker-based risk stratification, patients at high risk for progression are randomized to radiofrequency…
The aim of this study is to evaluate the feasibility of cryoablation in patients with dysplastic squamous epithelium in the esophagus.
This study will evaluate the efficacy of the CbFAS with the optimal safe dose on the conversion of Barrett's epithelium to healthy squamous cell epithelium in a larger cohort. Furthermore, the device performance of the improved CbFAS will be…