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Risk factors for colorectal cancer in patients with inflammatory bowel disease undergoing surveillance: a prospective cohort study

1. To confirm established and identify new risk factors for colorectal cancer in a prospective cohort of IBD patients undergoing regular surveillance. Dysplasia or colorectal cancer will be the primary outcome.2. To provide evidence that mucosal…

Effect of AN-PEP enzyme on gastrointestinal breakdown of immunogenic gluten epitopes in healthy subjects

Primary: • Assess effect of AN-PEP on gluten epitope degradation in the duodenumSecondary: • Assess effect of AN-PEP on gluten epitope degradation in the stomach• Assess effect of meal caloric content on the efficacy of AN-PEP on gluten epitope…

A study on Intestinal Disease and Lifestyle - Disease characteristics and lifestyle factors in inflammatory bowel disease and irritable bowel syndrome

At first, to describe the UC, CD, and IBS outpatient population in the Netherlands. Secondly to gain insight into disease and treatment characteristics, as well as lifestyle and clinical factors identified as potential risk factors of a UC, CD, and…

Safety and efficacy of interleukin-1 inhibitor anakinra for the amelioration of fever during neutropenia and mucositis in patients with multiple myeloma receiving an autologous hematopoietic stem cell transplantation after high-dose melphalan

The primary objective is to evaluate the safety and efficacy of anakinra in patients with multiple myeloma receiving high-dose melphalan (HDM) in the preparation for an autologous hematopoietic stem cell transplantation (SCT). Secondary objectives…

Efficacy and Safety of Multiple Faecal Microbiota Transfers in Acute Pouchitis

To study the effectiveness and safety of administration of FMT on acute pouchitis.