31 results
Primary Objective: 1. Determine if assessment of mucosal and serological immunological characteristics in combination with clinical indicators of disease behaviour and response to therapy can identify immune-based phenotypes with implications for…
Primary Objectives: - To test the feasibility of culturing patient-derived Barrett*s esophagus organoids- To test pharmacological and chemotherapeutical agents in vitro on the cultured organoidsSecondary Objectives: - To create a small Biobank (of…
The aim of the present study is to increase our understanding of the cost effectivity and the pathophysiology underlying the beneficial effect of autologous SCT. We will investigate the immunological mechanisms involved in the (re)induction of…
To determine the association between shLAIR-1/ hLAIR-2 levels in urine samples and clinical and endoscopic disease activity in patients with UC and CD
Primary objective: to study the effect of faecal transplantation in a phase II randomised placebo controlled design on simple clinical colitis activity index (SCCAI) and endoscopic Mayo score. Secondary objective: to study intra individual changes…
Primary: to analyze serum samples of adult EoE patients for IgE reactivity to recombinant allergens of common foods.Secondary: to demonstrate the presence of ILC2 in periferal blood of adult patients with eosinophilic esophagitis Tertiary: To store…
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
This study aims at revealing the pathophysiology of colonic IR in man, with a specific interest for cellular and inflammatory changes, barrier function and intestinal permeability, macroscopic mucosal changes, gene expression patterns and…
To determine the composition of immune cells and the expression of immunological factors in normal squamous esophagus, RE, BE and EAC.
Primary:* To investigate associations between genomic variation and occurrence of eosinophilic esophagitis. Secondary:* To systematically collect DNA samples and biopsy specimens for future genetic analysis.* We aim to collect clinical data on all…
To examine the effect of surgical trauma on mucosal perfusion, intestinal epithelial damage, the inflammatory response and potentially sepsis, following surgery remote to the abdomen in adults, children and neonates,
The aim of this project is to assess differential responses in immune cells derived from peripheral bloodof IBD patients concerning:Immunological phenotype in CD patients:1. defining the genotype in CD patient cohort2. production of interleukin-8…
The objective of the study is to gather as many DNA samples of partners of IBD patients and parents of adult IBD patients as possible. By assessing allele and genotype frequencies in IBD patients and the control cohort, novel genetic risk factors…
To determine whether the T1405N SNP in the CPS-1 gene is associated with lower plasma L-arginine concentrations in preterm infants and to determine whether the T1405N SNP in the CPS-1 gene is associated with a higher risk of NEC.
Primary Objective: To identify new immunological markers for therapeutic response to anti-TNF therapy in chronic granulomatous diseases.
The present study will evaluate if supplementation of the diet with riboflavin in Crohn*s disease patients will result in a similar increase in the number of F. prausnitzii as seen in the healthy volunteers. Potentially an even larger effect can…
We aim to study the role of diet in IBD in 2 subprojects: A) to study the prevalence of malnutrition in a consecutive cohort of IBD outpatients and to validate a malnutrition screening tool for IBD; B) To study the association of dietary patterns…
1. To validate the existing guidelines with prospective and retrospective data from this cohort by performing an upper endoscopy at baseline, one year after inclusion and subsequently every three years thereafter in order to assess the risk of…
To gain insight in the metabolic, microbiota and immunologic changes after bariatric surgery that drive NAFLD/NASH and weightless resulting in subsequent conversion of malign to benign obesity.
In this study it is aimed to investigate the genetic and immunological causes of VEO-IBD in order to improve diagnostics and therapies for patients with this intractable disease. In an explorative approach, state-of-the-art genome-wide screenings on…