208 results
The aim of the present study is to increase our understanding of the cost effectivity and the pathophysiology underlying the beneficial effect of autologous SCT. We will investigate the immunological mechanisms involved in the (re)induction of…
To demonstrate that food elimination therapy based on component-resolved diagnostics is an effective and acceptable treatment for EoO patients.
The primary objective is to determine whether PF 00547659 alters central nervous system immune surveillance in subjects with active, moderate to severe Crohn*s disease or active, moderate to severe Ulcerative Colitis by altering the absolute…
Primary objective:Pharmacokinetics/-dynamics of 124I-F8IL10 Secondary objective:Dosimetric parameters of arthritic joints and internal organs.
The evaluation of the safety and feasibilty of the Photopill capsule treatment in patients with Ulcerative Proctitis
Main objective: To validate novel biomarkers that can predict (non-)response to anti-TNF induction treatment in pediatric and adult IBD patients.Secondary objectives: To accurately describe pharmacokinetics of IFX and ADA in pediatric and adult IBD…
Primary Objective:To induce clinical response (CDAI decrease from baseline * 100 points) and/or remission(CDAI <150) following 12 weeks of treatment with one of two active doses ofGSK1605786A for qualification of subjects for enrolment into a…
Aim of this prospective study is to investigate the relation between non-trough serum IFX levels (4 and 6 weeks after infusion) and IFX trough levels (8 weeks after infusion) in patients with Crohn*s disease
The overall aim of this study is to assess the feasibility of implementing MRE for use in evaluating fibrosis in patients with Crohn*s Disease (CD) in a multicenter setting.The primary objective for this study is to evaluate *gain of enhancement* as…
The aim of the study is to gain more insight in the course of intestinal oxygenation, urinary I-FABP concentration, and plasma Citrulline levels (as markers for intestinal damage and recovery) after NEC in relation to time to full enteral feeding…
The primary objective is the determination of faecal reference values of calprotectin, elastase and alpha-1-antitrypsin after RYGBP.
Primary ObjectiveThe primary objective of this study is to assess whether high ADA serum levels lead to more side effects compared to therapeutic ADA levels in CD and UC patients who are in clinical and biochemical remission.Secondary ObjectiveThe…
To study MRI of the small bowel and colon in determining disease activity in patients with Crohn*s disease.
To determine the association between shLAIR-1/ hLAIR-2 levels in urine samples and clinical and endoscopic disease activity in patients with UC and CD
Primary objective: to study the effect of faecal transplantation in a phase II randomised placebo controlled design on simple clinical colitis activity index (SCCAI) and endoscopic Mayo score. Secondary objective: to study intra individual changes…
Primary: Safety and tolerability. Secondary: Effectiveness, quality of life, healthcare resource utilisation, work productivity.
1.1 Safety To evaluate the safety of long-term exposure with AMG 827 in subjects with Crohn*s disease 1.2 Efficacy * To evaluate the efficacy of AMG 827 as measured by the Harvey-Bradshaw Index (HBI) and the Crohn*s Disease Activity Index (CDAI)* To…
Study the very long-term efficacy (regarding reflux control) of antireflux surgery in children with severe GERD.
The primary objective is to assess the feasibility and accuracy of dynamic contrast enhanced MRI in diagnosing UC or CD in children as compared to endoscopy and abdominal ultrasound.The secondary objective is to assess the feasibility of dynamic…
Primary: • Assess effect of AN-PEP on gluten epitope degradation in the duodenumSecondary: • Assess effect of AN-PEP on gluten epitope degradation in the stomach• Assess effect of meal caloric content on the efficacy of AN-PEP on gluten epitope…