208 results
1. Determine the presence of lesions in the upper gastrointestinal tract in patients with a primary diagnosis of CD and UC, using endoscopy and histology, before starting medication.2. Asses the prevalence of histological lesions such as focal…
To assess the (additional) diagnostic value of faecal calprotectin in children, age 4-18 years, with symptoms suggestive for IBD, in a primary and secondary/tertiary care setting.
To examine the effect of surgical trauma on mucosal perfusion, intestinal epithelial damage, the inflammatory response and potentially sepsis, following surgery remote to the abdomen in adults, children and neonates,
1.To study the prevalence of diagnosed and undiagnosed/untreated coeliac disease in male-female couples visiting an infertility clinic.2. To study the relevance of routine antibody screening for coeliac disease in all patients with infertility…
We propose to assess the accuracy of MRI in a multicenter diagnostic accuracy study that will include a consecutive series of patients from the general population with suspected acute appendicitis. Patient acceptance and cost-effectiveness will also…
Primary: To assess the effects of visilizumab on the safety of subsequent salvage therapies in subjects who experienced disease progression in a previous visilizumab study and subsequently received salvage therapy (see Definitions).Subjects will be…
The aim of the study is to assess the accuracy and feasibility of contrast enhanced ultrasonography (CE-US), in the primary diagnosis and relapse during follow up of small bowel CD, compared to MR enterography. Furthermore we attempt to determine…
The aim of this project is to assess differential responses in immune cells derived from peripheral bloodof IBD patients concerning:Immunological phenotype in CD patients:1. defining the genotype in CD patient cohort2. production of interleukin-8…
Monitoring of serum drug levels may help to optimize dosing schedules and decrease the risk of infusion reactions and subsequent treatment failure. In the future we want to routinely measure anti-TNF levels in IBD patients that are treated with…
Evaluation of the incidence of liver enzyme abnormalities and hepatic steatosis in all type 2 diabetes mellitus patients (about n=1500) treated at the outpatient clinic internal medicine of the St Lucas Andreas Hospital
The objective of the study is to gather as many DNA samples of partners of IBD patients and parents of adult IBD patients as possible. By assessing allele and genotype frequencies in IBD patients and the control cohort, novel genetic risk factors…
Primary: To determine whether or not consistent exposures can be achieved in neonates and preterm infants with presumed GERD receiving oral doses of pantoprazole. Secondary: PK and PD assessment after single dose and steady state. Determination fo…
Primary: To test the safety and feasibility of autologous MSC therapy in patients with refractory Crohn*s Disease.Secondary:1 To evaluate clinical response in patients with refractory CD upon MSC infusion.2 To assess endoscopic- and histologic…
To determine the correlation between enhancement curves at DCE-MRI with T1-map and DWI and the level of histopathological activity.
Investigating the safety of adalimumab when administered in subjects with Crohn*s Disease as well as evaulating the efficacy of adalimumab for the induction and maintenance of clinical remission and fistula closure in subjects with moderate to…
At first, to describe the UC, CD, and IBS outpatient population in the Netherlands. Secondly to gain insight into disease and treatment characteristics, as well as lifestyle and clinical factors identified as potential risk factors of a UC, CD, and…
The goal of this study is to improve the diagnostic work-up of the small bowel in children suspected of IBD or diagnosed with CD and with suspicion of small bowel disease by comparing enteroscopy as gold standard to ultrasonography, Magnetic…
To study whether dynamic MRI can predict treatment response and long term outcome in patients with Crohn*s disease.
The primary goal of the study is the prevalence of NRH in patients with IBD, who have been treated for at least five years with azathioprin or 6-mercaptopurin. A MRI of the liver, using the Seiderer protocol, and a percutaneous liver biopsy will be…
To determine whether the T1405N SNP in the CPS-1 gene is associated with lower plasma L-arginine concentrations in preterm infants and to determine whether the T1405N SNP in the CPS-1 gene is associated with a higher risk of NEC.