213 results
Primary objectives:To determine the objective tumor response (CR + PR) after 3 weeks of erlotinibSecondary objectives: To describe predictive markers for response:- radiological response (FDG-PET/CT)- EGFR mutations (HER1)To determine (diseasefree)…
To analyze the value of lymphatic mapping in HNSCC patients with a previously treated neck.
Efficacy of sorafenib in NSCLC with a K-RAS mutation as determined by the Disease Control Rate at 6 weeks
Our goal is to study the effect of intravenous and oral contrast on the SUV in 18F-FDG PET-CT. The results will contribute to the adequate quantification of 18F-FDG-uptake in different clinical circumstances and the efficient use of combined PET-CT…
To measure the test-retest reproducibility of tumor blood flow and associated measurements as measured with H2[15]O PET-CT in patients with non-small-cell lung cancer.
The aim of this study is to assess the clinical activity of BMS-275183 in patients who have failed prior treatment.
The objective of the study is a prospective study to evaluate which type of TE shunt prosthesis is the most cost-effective.
To evaluate the feasibility and potential of sentinel node biopsy in patients with (recurrences of) laryngeal carcinomas and clinically negative neck undergoing total laryngectomy and neck dissection.
The primary objectives of the study are:- to establish the optimal dose of the combination for second-line therapy with NAMI-A and Gemcitabine (Phase I part)- to assess the response rate according to RECIST criteria (Phase II part) in advanced NSCLC…
The aim of this pilot study is to assess if the sildenafil leads to an increase in tumour blood flow in NSCLC.
To assess tumor reponse with FDG-PET-CT imaging early after start of concomitant chemo-radiotherapy in relation to cytological, histological and biological tumor characteristics. The ultimate goal is to reveal more insight in tumor reponse assesment…
Primary:•Efficacy of combination of erlotinib and sorafenib as determined by the rate of no progression at 6 weeks.•Determination of the impact of concomitant administration of sorafenib on the pharmacokinetics (PK) of erlotinibSecondary:•Efficacy…
To explore the influence of psychological factors - e.g. causal attribution, religiosity, mindfulness, Type D personality, benefit finding, and optimism - on survival, fatigue, depression, and health-related quality of life of stage IIIb/IV…
Primary objectives* 18F-FLT-PET/CT: - To correlate the percentage change in SUV between baseline (SUV-1) and early therapy (SUV-2) with pathological quantification (% of viable tumor cells) of the primary tumor after pre-operative chemotherapy in…
The purpose of this study is to assess the feasibility of the clinical use of 3T MR imaging for early glottic carcinoma.
Primary objective: the assessment of the maximal mean lung dose that is accepted to safely treat large peripheral tumors or 2 lung metastases simultaneously using SBRT. Secondary objectives:- evaluation of local control - evaluation of regional…
Herewith, we present a research protocol that allows us to examine feasibility and safety of checkpoint blockade neoadjuvant to standard of care (SOC) in a patient population in need for improved clinical outcome and in tumors likely to respond to…
We aim to explore the feasibility of immunological cell typing of endobronchial ultrasound (EBUS) guided fine needle aspirates (FNA) of lymph nodes and to develop immunodynamic biomarkers during SABR treatment.
The primary objective is to evaluate the ability of afatinib to control disease in pretreated patients with advanced non-small cell lung cancer harbouring HER2 exon 20 mutations.Secondary objectives are:* To evaluate secondary measures of clinical…
The primary objective of the study is to demonstrate the antitumor activity of LDK378.