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Prevention of breast cancer in high risk women by monitoring microrna expression in nipple aspirate fluid.

To establish biomarkers in nipple aspirate fluid, follow them in time and link them to breast cancer development at its earliest stage in women at high risk for breast cancer. Threshold values of biomarkers will be determined that point to a…

PRISMA study: Personalised RISk-based MAmmascreening

Objective 1: To collect information on risk factors and biomarkers in a screening cohort, develop a tailor-made risk prediction model and, subsequently, model the impact of adapting breast cancer screening policy to populations at varying levels of…

Radiotherapy of the breast: prone versus supine position. A planning study

To compare dose homogeneity and heart and lung doses in supine and prone position. Furthermore, the reproducibility of prone position will be compared to standard supine position, and we aim to identify those patients who benefit most from prone…

Feasibility of Nipple Fluid Aspiration in Dutch Women

- Assess the feasibility of the nipple aspiration procedure- Gain experience in methods and techniques of nipple aspiration - Identify factors that are associated with the fluid yielding status of nonlactating women- Assess the discomfort…

FeAsibility of a PReoperative, multimodal lifestyle InterventiOn in patients with breast cancer ReceivIng neoadjuvant chemotherapy (APRIORI-study)

The primary objective of this study is to investigate the feasibility of a multimodal prehabilitation programme consisting of MIET during neoadjuvant intravenous chemotherapy infusion, HITT and strength training during the last six weeks prior to…

Towards OPtimal TIming and Method for promoting sUstained adherence to lifestyle and body weight recommendations in postmenopausal breast cancer survivors: the OPTIMUM-study.

The OPTIMUM-study aims to gain insight into the optimal timing and method for promoting sustained adherence to lifestyle and body weight recommendations in PMBC survivors.The aim of the extra measurement during the second COVID-19 lockdown is to…

Two apples a day, keep the doctor away?

Primary objectives:- Investigate whether the activity of the bacterial enzyme β-glucuronidase and the abundance of β-glucuronidase-producing bacteria could be decreased by ingestion of 2 apples a day for a period of 6 weeks - Examine changes in gut…

Early diagnosis of breast cancer:
A multicenter, crOss sectional, study to assess microRNA expression in Nipple Aspirate Fluid, blood and tuMor material in women with primary brEast caNcer compared with healthy conTrols
The ORNAMENT study

The validation of microRNA expression for screening and prevention of breast cancer

Breast Cancer Biomarkers in Nipple Aspirate Fluid and Blood in Healthy Women

To be able to assess the value of new markers, we first analyze these potential markers in nipple aspirate fluid and blood from healthy women. The main goal of this study is to evaluate the normal expression levels of microRNAs in NAF and blood to…