238 results
The objective of our study is to to assess the diagnostic performance of 7T CE breast MRI in comparison to the current clinical standard of 3T MRI and histopathology on a intra-individual basis.
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioisotope; or radioisotope alone).The…
Is ductoscopy with white light and autofluorescent light a useful method for diagnosing precancerous breast lesions?
Primary objective:To determine which anthropometric parameters, LBM, total body weight (TBW) or BSA correlates best to docetaxel exposure (AUC). Secondary objectives:To determine if occurrence of docetaxel toxicity can be related to dose/LBM.To…
The primary objective is to assess the contribution of HER2-PET to subsequent anti-HER2-therapy decisions. Secondary objectives are assessment of clinical value of HER2-PET for the referring clinician; correlation of HER2-PET with standard…
The aim of this study is to evaluate androgen receptor (AR) and estrogen receptor (ER) expression non-invasively by means of PET imaging with the tracers 18F-FDHT and 18F-FES. To verify the PET results, the standard diagnostic biopsy will be…
Primary: To determine the response of 2B3-101 treatment as single agent or in combination with trastuzumab in patients with LM from breast cancer using the LM response scoreSecundary: - To determine the safety profile in patients with LM treated…
Primary goal: determine the diagnostic quality of CE-MRI scans acquired in supine positionSecundary goal: determine the accuracy of deformable image registration between prone CE-MRI and non-CE-MRI in supine position as an alternative option
The primary objective of this study is to evaluate the ability of PET-MRI ( PET, DWI and DCE-MRI) to detect and locally stage breast cancer in patients.
The aim of this study is to determine the effectiveness of the treatment (breast reconstruction) from the perspective of the patient's. By examining the results, the impact on the well-being and satisfaction, we will be able to customize the…
Clinical evaluation of dried blood spot (DBS) assay, by determining the ratio between DBS and serum levels of tamoxifen and endoxifen and to investigate if patients can obtain useful DBS at home.
The primary objective of this study is to evaluate the safety and tolerability of trastuzumab emtansine.
Primary goal of this study is to establish the *healthy* immune response in SLN of patients undergoing a prophylactic mastectomy.Secondary goal is to determine the incidence of IHC-positive SLN due to *benign* epithelial cell displacement
Objective: determine whether a Likert-type scale scoring system, specified for skin irritation reactions (erythema, itching, burning sensation of skin and general irritation of skin) can function as a tool to score the radiation-induced dermatitis…
The aim of the study is to optimize the selection of patients with ductal carcinoma in situ (DCIS), diagnosed on core needle biopsy (CNB), for a sentinel node biopsy procedure (SNP). In addition to the usual work up patients included in this study…
Primary Objective: Examining the value of ABVS in relation to current breast imaging techniques by: - comparison of ABVS findings with MRI findings. - comparison of ABVS findings with mammography and hand-held US. Secondary Objectives: - assessment…
Primary objective(s)Phase Ib:-Define the maximum tolerated dose (MTD) and/or recommended phase two dose (RPTD) of AUY922 in combination with Trastuzumab in patients with advanced or metastatic HER2-positive breast cancers.Phase II:-Evaluate…
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
The aim of this pilot-study is to examine the accuracy of MRL compared to current nodal staging methods. We expect an acceptable accuracy of the MRL based on earlier studies with gadofosveset enhanced MRI in rectum cancer patients. A positive MRL…
The aim of this project is to determine optimal communication strategies for prognostic disclosure in the palliative phase of breast cancer from a patient perspective. Study 1: To explore breast cancer survivors*, healthy women*s and oncologists*…