238 results
To be able to assess the value of new markers, we first analyze these potential markers in nipple aspirate fluid and blood from healthy women. The main goal of this study is to evaluate the normal expression levels of microRNAs in NAF and blood to…
Primary objective: To investigate the feasibility of PAM 2 in breast cancer imaging, characterizing the photoacoustic appearances of different types of malignant (stage 1A) and benign (stage 1B) lesions.Secondary objectives:- To test the measurement…
To develop and evaluate an adaptive MRI-only workflow for the MR-linac treatment in breast cancer patients eligible for APBI, regional lymph node irradiation or a radiotherapy boost on tumor positive lymph nodes. Furthermore, to investigate whether…
The objective of this study is the determination of the diagnostic quality (sensitivity, specificity, positive predictive value, negative predictive value) for the detection of malignant or pre-malignant tumor with the DELSENI in comparison with…
RAD1901, a novel selective ER modulator (SERM)/selective ER degrader (SERD), has previously been demonstrated to modulate the ER in both nonclinical and clinical studies. The aim of this study is to visualise and quantify ER-binding sites during…
Our primary objective is to test the feasibility of a tailored physical therapy program especially designed for metastatic breast cancer patients. As a secondary objective we will evaluate the impact of the program with regard to goal attainment,…
The primary objective of this trial is to study the effect of the moderate CYP3A4 inhibitor erythromycin on the pharmacokinetics of palbociclib, measured as AUC0-24h, Cmax and Cmin.The secondary objective of this trial is to compare the incidence…
To determine a safe dose combination of carboplatin-cyclophosphamide combined with atezolizumab fixed dose in advanced breast cancer and gynaecologic cancer (ovarian, cervical and endometrial cancer).
CESM is a novel mammography technique that has been shown to be superior to conventional full-field digital mammography (FFDM). In a CESM exam, iodine based contrast agents, similar to those used in for example computed tomography (CT) exams, are…
To proof that within the BR grade 3 ER/PR+ and HER2+ breast cancers the percentage of HRD is substantially higher in the metastatic lesions compared to primary breast cancers.
The primary objective of this study is to compare analgesic efficacy of paravertebral block (PVB) with erector spinae plane block (ESPB) in patients undergoing BCS. Since post-operative pain is treated with analgesics we will both assess pain scores…
The primary objective is to evaluate the SN detection rate of the PGC in breast cancer compared to CGC imaging.
In this side-study proposal we plan to gain more insight in tumor characteristics in order to predict which patients will have a high chance of a long progression-free survival. Study objectives: 1. It is proposed to compare progression-free…
Part 1: Determine the Recommended Phase II Dose
The goal of the trial is to investigate the safety and efficacy of SAR566658, if it is provided to CA6 protein positive metastaticTBN breastcancer patients.
The primary objective is to determine if metastatic breast cancer patients with HER2-negative primary tumors but with at least one HER2-positive CTC benefit from trastuzumab-containing chemotherapy. Secondary objectives are to determine the impact…
Primary objective: Estimate the added value of using hydrogel in addition to clips only in terms of the Conformity Index (Cx) of tumorbed delineationSecondary objectives: Estimate the Cavity Visualisation Score (CVS), distance between the center of…
To assess the safety and tolerability and to define the dose limiting toxicities (DLT) and maximum tolerated dose (MTD) of BMS-986158 as for subjects with selected advanced solid tumors.