238 results
Primary Objective: 1. A search for (objective) EEG predictors (independent variables) for both acute and chronic postoperative pain (dependent variables) after breast cancer surgery. The EEG variables are derived from the above mentioned five…
To assess the effectivity and safety of 1.0 molar gadobutrol (Gadovist®) for breast MRI
To compare dose homogeneity and heart and lung doses in supine and prone position. Furthermore, the reproducibility of prone position will be compared to standard supine position, and we aim to identify those patients who benefit most from prone…
Primary objective:To compare the specificity of multiple voxel MR spectroscopy with MRI.Secondary objective: To decrease the number of false positive diagnostic outcomes by using multiple-voxel MR-spectroscopy and therefore to reduce benign biopsies…
The primary aim of the study is to develop the Dutch version of the FCRI (Fear of Cancer Related Inventory)
The objective of this pilot-study is to investigate if the current dosage of tamoxifen supplied to women with estrogen receptor positive breastcancer who opt for embryo- or oocyte freezing is protective during the whole period of hormone stimulation…
To compare Clinical Target Volumes after RFIB (CTV-RFIB) and after BCS (CTV-POC).
In the present study, we aim to perform a feasibility study to prove that 89Zirconium-bevacizumab PET scanning can indeed detect all small primary breast cancer lesions. Data from the present study may be used to design further studies with regard…
The primary objective of this pilot study is to check the feasibility of the main study. The primary objective of the main study is to identify a cut-off score under which alopecia can be prevented by scalp cooling.
The primary objective of this study is to assess the objective response rate (ORR, the percentage of treated patients in whom the tumor significantly reduces in size or becomes non-detectable) of SAR240550 administered as a 60min intravenous…
The prime objective of the proposed study is to apply treatment modeling for superficial hyperthermia in a well-defined group of patients to investigate the potential of predicted 3-dimensional energy as source for a dose parameter that is…
Primary Objective:* To investigate the value of the Softscan in the early prediction of tumor response (RECIST criteria) to neoadjuvant chemotherapy or hormonal therapy in breast cancer. Secondary Objective:* To assess the accuracy of the Softscan…
1. To investigate the feasibility of photoacoustic breast cancer imaging as embodied in the first generation photoacoustic mammoscope; 2. To correlate the photoacoustic images to conventional diagnosis of the breast and therefore to find…
The primary objectives of this study are (1) to assess uptake of bevacizumab-IRDye 800CW in breast cancer, surrounding tissue and lymph nodes as measured in surgical specimens after a single intravenous administration of 4.5 mg and (2) to evaluate…
Primary objective: To determine pharmacokinetic interactions between milk thistle and docetaxel and between milk thistle and tolbutamide in patients with cancer.Secundary objective: To determine the safety of the use of milk thistle in combination…
The main objective of this feasibility study is to assess the treatment accuracy of MR-HIFU in patients with breast cancer using a dedicated MR-HIFU breast system. A secondary objective is to determine the safety.
In this pilotstudy we are planning to investigate in a relatively low number of patients if [18F]-choline uptake will decrease after 2 to 3 weeks of trastuzumab +/- pertuzumab therapy in morphologically responding patients (as noted after 12 weeks…
Primary Objective:• To assess the safety and tolerability of 2B3-101 when administered intravenously (IV) as single agent in patients with solid tumors and brain metastases or recurrent malignant glioma in order to determine the Maximum Tolerated…
Research question: Is microbubble-enhanced Iodine-125 seed localization an accurate tool for preoperative identification of the sentinel lymph node in women with breast cancer, in terms of diagnostic accuracy, sensitivity, feasibility, patient…
Primary objective: to evaluate safety of everolimus in postmenopausal women with estrogen receptor positive locally advanced or metastatic breast cancer that is refractory to NSAIs.Secondary objective: to evaluate adverse events grade 3 and 4 in the…