238 results
With this study we will investigate whether it is possible to dituinguish benign from malignant lesions with ARFI. This will decrease the need for additional biopsy. Furthermore it may decrease the false positive ratio of mammography and 2D…
Early detection and prediction of cardiotoxicity in chemotherapy-treated patients with the use of the new high sensitivity troponin t assay.
The objective of the study is to assess which outcomes are most important to patients, so that we can inform them better and contribute to decision making. If patients, depending on treatment or age, consider PROMSs more or less important than…
Feasibility of ultra high field 7.0 Tesla MR Spectroscopy for monitoring neo-adjuvant therapy efficacy.
To evaluate the BreathLinkTMin women with breast cancer and in cancer-free controls, in order to identify their breath VOC profiles and to develop multivariate predictive algorithms that can identify women with breast cancer.
The BASIS study will analyze the full cancer genome of breast cancer subtype ER+ HER2-.
Analyze processes related to DNA-damage in oocyte development and early-developmental stage embryos from BRCA1/2-mutation carriers compared to controls, using immunohistochemistry and RNA-Seq technology.
Clinical evaluation of dried blood spot assay for the determination of tamoxifen and endoxifen levels
Primary objective:To establish the accuracy of pretreatment 7T MRI to identify low-risk breast cancers. This will be done by identifying preoperative imaging-based characteristics related to risk factors of cancer relapse in the resection specimens…
Primary: To estimate the MTD or RDE and preferred dosing schedule of LJM716 when administered in combination with trastuzumab in patients with HER2 overexpressing metastatic breast cancer or gastric cancer.Secondary: Safety and tolerability, PK, PD…
Primary objective:Analyze the value of pneumoproteins, everolimus exposure, pulmonary function tests, distinct radiological patterns, baseline patient characteristics and the development of skin toxicity or oral mucositis for the prediction of the…
1. To evaluate wether ABVS could replace HHUS in women <30 year with focal breast signs2. To evaluate the performance of ABVS in comparison to HHUS in patients with high suspicion of breast cancer3. To start a pilot study to compare ABVS with…
The aim of this study is to define the specific changes in skeletal muscle composition and function, systemic inflammation and nutritional intake and physical activity levels, during cancer treatment. To investigate this, we will include 13 female…
To detemine the optimal imaging modality and moment in time to delineate RT target volumes in breast-conserving therapy.
The objective of this study is to find answers to the question which breast reconstruction technique gives the highest quality of life for these women. Researching the outcome, psycho social and quality of life impacts on women who undergo breast…
- To examine the effects of cytochrome P450 induction by rifampicin on the metabolism and pharmacokinetics of tamoxifen and its metabolites. Induction of cytochrome P450 enzyme expression (including CYP3A4, CYP2C and CYP2D6) by rifampicin will…
The aim of this study is to quantify residual ER binding sites during fulvestrant therapy, compared to the tracer uptake prior to fulvestrant therapy.
Primary objective is to assess differences in endogenous hypoxia markers (CA9, PAI-1, VEGF [Rademakers et al. 2008]) and autophagy (LC3b [Rouschop et al. 2010]) before and after short-term pre-surgical treatment with HCQ in breast cancer patients.…
We estimate that the anthracycline and cyclophosphamide dose could be significantly (>=15%) increased in at least 15% of ACC-treated patients. Therefore, in order to diminish the risk of under-dosing ACC, we aim to develop a neutrophil-guided…
This study will evaluate the significance of TISENO for early detection of mamma carcinomas and benign breast diseases.