238 results
The principle aim of this study is to characterise all of the genetic alterations that are present in different types of breastcancer by comparing the cancer genome to it's matched normal genome.The primary goals of this ICGC project, which…
To study (in vitro) if dendritic cells can be cultured with cells obtained from peripheral blood of patients with either m. myeloma, ovarian cancer or breast cancer. Thusfar we worked with cells from healthy volunteers. Before performing clinical…
To investigate the relationship fo the pharmacokineticsof the probe drug (dextromethorphan) and tamoxifen.
To evaluate the effect of HSP90 inhibition by AUY922 on VEGF by means of 89Zr-bevacizumab PET. Primary endpoint: measurement of decreased VEGF compared to baseline. A decline is defined as a decrease of at least 30% in mean Standardized Uptake Value…
This study investigates 3 different aspects of RFA treatment:1. Feasibility and safety of RFA treatment in elderly patients ( > 70 years) with T1 breast carcinoma who are not or less fit for surgery.2. Efficacy of RFA treatment in elderly…
The aim of this study is to evaluate patients and surgeons aesthetic satisfaction and to assess the impact on self-esteem with immediate breast reconstruction using DIEP- flap procedure.
MULTICENTER FEASIBILITY STUDY OF THE SENTINEL NODE PROCEDURE IN PATIENTS WITH MULTIPLE BREAST TUMORS
The aim of the study is to validate the sentinel node procedure in breast cancer patients with multiple tumors and to investigative whether an intratumoral injection of the radiopharmaceutical in each tumor will result in additional sentinel nodes…
This study aims at evaluating whether indocyanin green (ICG) enhanced intra-operative near-infrared fluorescence (NIRF) imaging is as good as or even better than the standard technique (technetium-99 labeled colloid and Patent Blue) in detecting…
This research project is directed at assessing tumor response to radiotherapy. The goal of the study is to develop a gene expression profile that predicts response to radiotherapy in early breast cancer patients, allowing for optimal treatment…
Research question and hypothesis Research questions1 Are there tumourmarkers available which can be measured intracellular by flowcytometry during neoadjuvant treatment of patients with breast cancer?2 Can we measure the effect of neoadjuvant…
Primary objective: To evaluate the safety of Gemcitabine and Lapatinib in combination for the treatment of advanced breast cancer.Secondary objectives: Assessment of the effect of Gemcitabine and Lapatinib on the pharmacokinetics of each other and…
Detection of breast carcinoma with an ICG enhanced optical imaging device in breast cancer patients.
Ergonomics and function of the imaging system - the NIRF imaging system should not interfere with the standard lumpectomy procedure and used safely by the surgeon while detection of ICG within the tumour takes place. Duration: 1,5 hour clinical…
To propose a regional staging protocol, lymphatic mapping and sentinel node biopsy, for patients with locally recurrent breast cancer in the absence of guidelines for regional staging procedures and to registrate data derived from this study.
To investigate the clinical diagnostic performance of (extremely) low-dose views in standard digital mammography and relate this to physical image quality measures.
Feasibility of 7T beast MRI for the detection of breast cancer.
Primary objective (dose escalation arm): To determine the MTD of AUY922 as a single agent.Primary objective (phase II): At the MTD two further arms will be expanded to assess response (breast cancer)
1. To determine the diagnostic accuracy of the electronic nose in the identification of lung cancer in new (referred for suspicion of lung cancer) patients based on the algorithm developed in the SCENT study part 1 (training-set).2. To determine the…
The study objectives are:1. Getting insight into the biological origin of the typical serum protein profile in breast cancer by comparing the protein profiles in breast tissue of benign breast disease patients and primary breast cancer patients with…
The purpose of this study is to determine whether optical mammography performed on the PMS DOT has a potential in breast cancer diagnosis in patients with suspicious breast lesions.
The main goal of neoadjuvant therapy should be a pathological complete response (pCR), because pCR more accurately predicts improved patient outcome and prolonged survival. In the present study, pathological response will be evaluated by The Miller…