238 results
The main objective of this study is to demonstrate treatment efficacy of MR-HIFU ablation of breast cancer. Effective treatment is defined as 100% necrosis of the targeted primary breast tumor. The secondary objective is safety of the MR-HIFU…
This study has been transitioned to CTIS with ID 2024-515080-54-00 check the CTIS register for the current data. Primary objectiveTo determine the pathological complete response rate per cohort
The OPTIMUM-study aims to gain insight into the optimal timing and method for promoting sustained adherence to lifestyle and body weight recommendations in PMBC survivors.The aim of the extra measurement during the second COVID-19 lockdown is to…
The purpose of the study is to investigate the feasibility of a preoperative, single dose, ablative partial breast radiation treatment in patients with early stage breast cancer. This study aims to present a concept that could resolve to some extent…
This study has been transitioned to CTIS with ID 2024-513217-12-00 check the CTIS register for the current data. To determine the activity and safety of nivolumab (as monotherapy or in combination with other immunomodulatory treatments) after…
The main goal of this study is to study the accuracy (sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and false negative rate (FNR)) of dedicated axillary hybrid PET/MRI for the detection of negative…
The aim of the study is to improve the positioning of patients who are irradiated on the breast. Optical surface scanning will be used and the precision, patient friendliness, and process optimization are studied.
The REPEAT trial is a feasibility trial of repeat breast-conserving therapy consisting of preoperative single-dose partial breast irradiation and breast conserving surgery to assess the rate of grade 2 or higher acute radiotherapy- and surgery-…
In this study, we aim to identify the diagnostic value of indocyanine green (ICG) fluorescence imaging for SLNBs via the mastectomy incision.
The PAPBI-3 trial is a phase I/II interventional trial assessing the toxicity and feasibility of repeat breast conserving therapy with preoperative partial breast irradiation in female patients aged 51 years or older with ipsilateral recurrent or…
Sensitivity of CEBCT for DCIS when focal enhancement around calcifications is deemed positive, and no enhancement is regarded as a negative test outcome.
In the current phase 2 study we will investigate the efficacy of the combination of fulvestrant and alpelisib directly after progression on 1st or 2nd line therapy with fulvestrant with or without a CDK 4/6 inhibitor in patients with HR+HER2-…
a. Staging of women with breast cancer, particularly those with extensive carcinoma in situ (DCIS):1) The concordance of tumor extent between CEBCT and large section histopathology2) The non-inferiority of CEBCT to contrast enhanced breast MRI for…
Based on the data as described above, we hypothesize that the FES-PET heterogeneity score can predict progression free survival (PFS) in individual patients prior to start of 1st line endocrine treatment and CDK 4/6 inhibition in ER+ advanced breast…
Primary objectives -To determine whether real-time tumor visualization using targeted fluorescent imaging during breast conserving therapy in breast cancer patients can be achieved intraoperatively and results in adequate assessment of the tumor…
Primary:• To evaluate the clinical benefit rate (CBR) of ixabepilone Secondary:• To evaluated progression free survival (PFS)• To evaluate overall survival (OS)• To evaluate objective response rate (ORR) defined as Complete Response (CR) and Partial…
The goal of this study is to assess the efficacy of single dose preoperative radiotherapy in patients with low-risk breast cancer. In this context, efficacy is the proportion of patients achieving a pathologic complete response after single dose…
Primary objectives:- Investigate whether the activity of the bacterial enzyme β-glucuronidase and the abundance of β-glucuronidase-producing bacteria could be decreased by ingestion of 2 apples a day for a period of 6 weeks - Examine changes in gut…
The main goal is to show in postmenopausal estrogen receptor positive breast cancer patients the influence of:Microbiota composition and ß-glucuronidase activity on systemic endoxifen levels during tamoxifen therapy.
Primarily, we will evaluate and compare postoperative sensation between different sensate autologous breast reconstructions. Secondarily, we will evaluate and compare quality of life measured by the validated BREAST-Q questionnaire between the…