238 results
This study has been transitioned to CTIS with ID 2024-516204-42-00 check the CTIS register for the current data. The primary objective of the study is to evaluate if treatment with a non-steroidal aromatase inhibitor combined with CDK4/6 inhibition…
Compare the CTC recovery of the CellSearch system for CTC detection to a newly developed method for CTC detection.
Part A: Determine the performance of using 4D DCE-BCT for tumour staging. Part B: Determine the performance of 4D DCE-BCT in monitoring of treatment response and prediction of final treatment outcome based on early response in patients that undergo…
This study has been transitioned to CTIS with ID 2024-518192-61-00 check the CTIS register for the current data. To evaluate safety and feasibility of neoadjuvant chemotherapy-free regimen with trastuzumab, pertuzumab and tucatinib in stage II-III…
This study has been transitioned to CTIS with ID 2024-518036-36-01 check the CTIS register for the current data. To prove that the RECAP test has the potential of selecting patients who are sensitive to treatment with the PARP inhibitor talazoparib…
This study has been transitioned to CTIS with ID 2024-516205-23-00 check the CTIS register for the current data. To evaluate efficacy of image-guided de-escalating chemotherapy in the presence of dual HER2-blockade with Herceptin® and pertuzumab in…
The purpose of the pilot study is to assess acute post-surgical complications following mastectomy and immediate breast reconstruction after NART. We hypothesize that NART will avoid the negative effects of PMRT on the capsule of an implant, or on…
Primary objective:To describe the overall treatment effect of T DXd in HER2+ MBC patients with or without baseline brain metastasisSecondary objectives:- To describe the treatment effect on the development and progression of brain metastasis in…
- special attention for the development and harmonization of the pre-analysis of liquid biopsy, for blood as well as urine, andnext to this for ctDNA- special attention for the detection of PIK3CA mutations in blood and urineSimultaneously also the…
To assess whether minimally invasive nonsurgical microwave ablation (MWA) followed by postprocedural MRI scan can be an alternative treatment for breast surgery in early stage breast cancer: a non-inferiority study .Is the quality of life, cosmetic…
Comparing the release of DAMPs and subsequent immune suppression after breast-conserving surgery versus mastectomy.
The primary objective is to prospectively quantify the geometric uncertainty of CK-APBI and to propose a validated PTV margin.Secondary objectives are: - To evaluate the success rate of using surgical clips as fiducial markers- To evaluate the…
Cohort 1 (HER2-positive/amplified MBC): MCLA-128 + trastuzumab ± vinorelbine Primary objective:• Evaluate efficacy of MCLA-128 combined with trastuzumab ± vinorelbine in terms of clinical benefit rate (CBR) at 24 weeks based on RECIST 1.1 (per…
Primary Objective: To investigate the association between the everolimus trough levels over time and the onset of National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) v4.0 grade 2, 3 or 4 late AEs (i.e. from treatment…
To compare the plasma concentration of edoxaban in women with breast cancer before and during treatment with tamoxifen.
The aim of our study is to assess the psychosocial impact of an individualised breast cancer lifetime risk score for unaffected healthy first degree relatives from genetically unexplained (i.e. negative for pathogenic variants in BRCA1, BRCA2, CHEK2…
The primary objective is to identify the relevant domains of health-related quality of life as experienced by patients who are previously treated with neoadjuvant chemotherapy for HER2-positive breast cancer. Secondary Objectives: * To adjust…
The primary objective is to determine the impact of HER2 expression in CTCs taken at baseline on outcome to AIs in metastatic breast cancer patients with an ER-positive primary tumor. Secondary objectives are to determine impact of HER2 expression…
Primary: To characterize the safety and tolerability of PDR001 in combination with LCL161, everolimus, HDM201, QBM076 or panobinostat and to identify recommended doses and schedules for future studies.Secondary: To characterize changes in the immune…
The PROBI is a phase I/II study assessing the feasibility of preoperative whole breast irradiation with an additional boost to the tumor, with or without regional lymph node irradiation in female patients with early breast cancer, who will undergo…