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An Open Label Study to Investigate the Pharmacokinetics (Absorption, Distribution, Metabolism, and Excretion) of Omacetaxine Mepesuccinate Following Subcutaneous Administration of [14C]c in Patients with Relapsed and/or Refractory Hematologic Malignancies or Advanced Solid Tumors.

Primary Objective: The primary objective of the study is to quantitatively determine the pharmacokinetics (absorption, distribution, metabolism, and excretion) of [14C]omacetaxine mepesuccinate and its metabolites in patients with relapsed and/or…

Use of individual PK-guided pazopanib dosing: A feasibility study in patients with advanced solid tumors

primary• To determine the safety and feasibility of PK guided dosing of pazopanib secondary• Evaluation of the dried blood spot procedure• To determine the objective response rate (according RECIST 1.1)• To determine the time to tumor progression…

Development of an assay for detection of Circulating Endothelial Cell (CEC) and Circulating Endothelial Progenitor cell (CEP) by fluorescence-activated cell sorting (FACS) in cancer patients and healthy individuals.

Produce a reproducible method for enumeration of CECs and CEPs in peripheral blood in order to further study the usefulness of CECs and CEPs as a biomarker in LDM therapy.

Long-term treatment for cancer patients with deep vein thrombosis or pulmonary embolism - a randomized open label study

The primary efficacy objective is to evaluate whether LMWH is superior to VKAs in the long-term treatment of symptomatic VTE in cancer patients who completed 6 to 12 months of anticoagulant treatment. Two aspects are important: the efficacy with…

Predictors for Chemotherapy Tolerance and Toxicity in Elderly Cancer Patients

The objective of this study is to Identify relevant geriatric instruments and compose a clinical model to predict tolerance and toxicity in elderly cancer patients who are treated with chemotherapy for their (metastasized) malignancy.

Phase 1-3 development of a questionnaire for assessing sexual health in cancer patients:
A cross cultural project of the EORTC Quality of Life Group

The aim of this project is to develop a comprehensive EORTC questionnaire for assessing sexual health for male and female patients with cancer. Given the lack of a sexual health related measure that can be used in clinical trials and in clinical…

A two parts, biomarker study to identify genetic aberrations predictive for response on Everolimus in solid tumors without regular treatment options (CPCT*03)

Primary objective first part: analyse a set of 1951 genes for prediction of response measured by progression free survival ratio (TTP1:TTP2) on mTOR inhibition.Primary objective second part: to assess the ratio of progression free survival (TTP1:…

Using advanced MRI techniques to improve the planning treatment for head-neck hyperthermia and radiotherapy

The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.

An open label phase I dose finding study of BI 853520 administered orally in a continuous dosing schedule in patients with various advanced or metastatic non-hematologic malignancies

Primary objective: to determine the safety and tolerability of BI 853520 monotherapy by defining the MTD (maximum tolerated dose) and recommending the dose for further trials in the development of this compound.Secondary objectives: A) determination…

Cryopreservation of prepubertal testicular tissue for future autologous transplantation of spermatogonial stem cells: preserving fertility in young boys with cancer

To preserve testicular tissue of young boys with cancer for possible autologous transplantation in the future if infertility has become apparent.

Measurement of tumor kinase inhibitor concentrations using PET imaging in patients with advanced solid malignancies

The main objective of this study is to determine whether tumor concentrations of kinase inhibitors at pharmacological active doses can be predicted from PET studies using tracer amounts (microdosing) of corresponding radiolabeled kinase inhibitors.…

A Non-randomised, Open-label, Sequential, Multicentre, Two-part, Phase I Study to Assess the Effect of Rifampicin, a CYP Inducer, on the Pharmacokinetics of Olaparib Following Oral Dosing of a Tablet Formulation in Patients with Advanced Solid Tumours

* The primary objective of this study is to investigate the effect of rifampicin on the pharmacokinetics (PK) of olaparib following oral dosing of the tablet formulation in patients with advanced solid tumours.* The secondary objectives are to…

An Extension Study to Evaluate the Safety of Veliparib as Single Agent Therapy or in Combination with Chemotherapy in Subjects with Solid Tumors

This study is designed as an extension to other veliparib clinical studies. The primary objective of thisstudy is to evaluate the safety and tolerability of veliparib monotherapy, veliparib in combination withcarboplatin/paclitaxel, or veliparib in…

A Phase 1, Open Label, Exploratory Study for the Intra-operative Imaging of Folate Receptor Alpha Positive Ovarian, Lung, Breast Cancer and Parathyroid adenomas using the Tumor Specific Imaging Agent EC17

To assess the safety of a single dose of intravenous EC17 injection in patients with ovarian, lung, breast cancer and parathyroid adenomas. To assess concordance of fluorescent signal and tumor status of resected tissue, in the case of ovarian, lung…

Nitroglycerin as a sensitizer in the treatment of non small cell lung cancer: ;a phase II trial.

Demonstrate an increase of 2-year overall survival (OS) of 15 % (from 50% to 65 %) vs historical controls of the addition of nitroglycerin to radiotherapy (±chemotherapy) of stage I-IV NSCLC.

An Open-Label, Single Arm, Phase 1 Study of the Pharmacokinetics and Safety of Carfilzomib in Subjects with Advanced Malignancies and Varying Degrees of Hepatic Impairment

The primary objective of this study is to assess the influence of hepatic impairment on area under the curve (both area under the curve, from time 0 to the last concentration measured [AUC0-last] and area under the curve, from time 0 extrapolated to…

Feasibility test of a respiratory challenge in the MRI to image the vascularity of the brain and the head and neck area.

The primary objective is to test the feasibility of MRI measurements at 3T and 7T under dynamic hypercapnic or hyperoxic conditions controlled by digitally regulated respiratory challenges in volunteers.

An open label, multi-center, extension study to evaluate long-term safety and tolerability of dovitinib in patients with solid tumors, who continue to receive treatment with dovitinib (TKI258) in Novartis-sponsored, single agent dovitinib studies, which have fulfilled the requirements for the primary objective, and are benefitting from continued dovitinib treatment as assessed by the investigator

To collect long term data on safety and tolerability of dovitinib monotherapy.

The predictive value of PET-CT and PET-DW-MRI early during chemoradiotherapy for locoregional control of advanced stage head and neck cancer

Primary Objective:To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node…

Phase I study: to determine the biological activity of two HPV16 E6 specific peptides coupled to Amplivant®, a Toll-like receptor ligand in nonmetastatic patients treated for HPV16-positive head and neck cancer

Primary objective: to determine the biological activityof Hespecta that is able to induce HPV16 E6-specific T-cell immunity within a proposed dose escalation of 1, 5, 20 or 50 µg/peptide - conjugate in patients treated for HPV16+ OSCC.Secondary…