324 results
The aim of the study is to develop PD-L1 PET/CT imaging in patients with advanced HNSCC to non-invasively image PD-L1 expression in tumours and to determine the correlation with response to durvalumab. The studie will be divided into 2 parts:1:…
4.1 Primary Objective• To determine the MTD and to establish the safety profile of enapotamab vedotin in a mixed population of patients with specified solid tumors. 4.2 Secondary Objectives• To evaluate the safety laboratory parameters of enapotamab…
Primary: To characterize safety and tolerability of MIW815 (ADU-S100) given with PDR001 and identify recommended doses and schedule for future studies.Secondary: Anti-tumor activity. Pharmacodynamics (PD). Pharmacokinetics (PK).
Pathologic validation of tumour volume, location, and microscopic extension on 7 Tesla MR images using whole mount histopathology.
we propose a pilot PK study to assess: 1) The interaction between aprepitant and dexamethasone in children using both antiemetogenic agents at the same time, to optimize the dose of both agents in children of different age groups.2) The feasibility…
Primary: efficacy of dabrafenib and trametinib combination therapy compared to placebo with respect to overall response rate in subjects with rare BRAF V600E mutated solid tumors or hematologic malignancies.Secondary: duration of response,…
To assess the feasibility of cRGD-ZW800-1 to visualize tumors in real-time using dedicated NIR fluorescence imaging systems
The primary objective is to compare18F-MFBG PET-CT imaging for neuroblastoma patients with the current standard of imaging, 123I-MIBG SPECT, using the SIOPEN score for skeletal lesions and the number of detected soft tissue lesions as endpoints.
BI 905677 is a drug being developed for the treatment of cancer. The main purpose of this study is to investigate how the study drug BI 905677 spreads in the body and in the tumor. This is examined using a technique called Positron emission…
In this explorative study, we aim to:• Analyze neoantigens expressed on different tumors of CMMR-D patients, to identify possible target antigens for DC vaccination studies.• Investigate the presence of pre-existing immune responses against…
The primary objective is to evaluate the uptake, including the distribution, of [68Ga]Ga-PSMA-11 in enhancing glioma and brain metastases eligible for (re-)resection by performing [68Ga]Ga-PSMA-11 PET/MRI scans, in order to study the potential of…
Primary Objective: After ex vivo confirmation that BD injected around LC in a laryngeal surgical specimen is not spreading into tissues beyond the tumor, the detection of SLN by a technique of injecting BD via a flexible laryngoscope using a working…
The primary objective of this study is to establish the relationship between microdose and therapeutic dose docetaxel pharmacokinetics. Our secondary objective is to develop a limited sampling model of microdose docetaxel pharmacokinetics to predict…
To determine markers related to early ageing and senescence in AYA cancer patients before and after systemic therapy, in order to assess treatment-related early vascular ageing and associated tumour and patient characteristics.
Primary:Long-term safety of nivolumab in participants on treatment and in follow upExploratory:To follow participants who have completed therapy and are in or have completed follow-up on a parent study investigating nivolumab or nivolumab…
The aim is to provide enough evidence through RifRam model analysis, physical tests and clinical study of 10 patients that our new type of personalized mandibular implant is safe to use, resulting in significantly fewer complications and can be…
1) To assess uptake of [18F]BMS-986192 in tumor lesions before and after treatment with nivolumab, in relation to [18F]-FDG uptake as potential whole body biomarker for response. 2) To evaluate safety and tolerability of neoadjuvant nivolumab 3) To…
Primary objective: To investigate the feasibility of the adaptive radiotherapy scheme.Secundary objectives:To examine the toxicity of the adaptive RT schemeTo investigate the locoregional tumor controlTo examine the prognostic value of the different…
The aim of this study is to investigate the differences in organ-specific protein turnover rates by means of stable isotope labelled amino acid infusion in patients undergoing surgery. Primary objective:To compare protein synthesis rates, expressed…
Primary objective To determine the relation between age and pharmacokinetics of docetaxel, paclitaxel, doxorubicin, gemcitabine, vinorelbine and capecitabine, respectively. Secondary objectives All here cited secondary endpoints will be separately…