212 results
The overall aim of the proposed longitudinal cohort study is to expand our understanding of health-related work functioning among cancer survivors, who returned to work after first cancer diagnosis and treatment with curative intent during 18 months…
The aims of the present study are: 1. to create a tracer kinetic model for quantification of [18F]FCH and simultaneously validate a simplified quantitative method, and 2. to assess the repeatability of the latter method.
The objectuve of the study is to investigate the optimal geometry parameters and B-values by a acceptabel signal to nois ratio, for a diffusion sequention for MRI of the pancreas. It wil be investigate by a literature study and a practice study. The…
With this pilot study our aim is to lower the radiation dose. Therefore we will scan 5 patients at 100kV and 5 patients at 80kV and determine the resultant decrease in radiation dose, aiming at a dose comparable with a normal diagnostic CT scan with…
The aim of this pilot study is to provide insight into the technical functioning, usability, acceptability, comprehensiveness, and feasibility of the telemonitoring intervention and care organisation, for both patients as well as participating…
This quantitative research project was preceded by a qualitative study (Sexuality in people with a limb amputation and their partner: a qualitative study; METc 2010/179). The aims of the current study are to explore:- which sexual problems occur in…
Primary Objective: - to study the influence of administration aprepitant (Emend ®) on the clearance of fentanyl, in patients using a stable dose of the fentanyl patch (Durogesic ®).Stable dose is defined as using the same dose of fentanyl during at…
This study will investigate if it is possible to perform the EGFR mutation test using blood samples. If successful, this study may mean that in the future, the mutation test can be done using a blood sample, and that patients may not need to have…
The main objective is to compare the clinical effectiveness of MRgUSBx versus MRgMRBx to provide evidence that MRgUSBx can partly replace MRgMRBx. Secondary objectives are: to determine the actual spatial targeting accuracy to further investigate if…
To provide continued bevacizumab therapy as single agent or in combination with an anti-cancer drug to patients with cancer, who were previously enrolled in a F. Hoffmann-La Roche (Roche)/ Genentech sponsored bevacizumab study (i.e. the Parent, P-…
The primary objective is to determine if disease associated lesions in patients with VHLD can be visualized with 89Zr-bevacizumab PET scans. Secondary objectives are to explore if 89Zr-bevacizumab PET imaging can differentiate progressive from non-…
The ultimate goal is to develop an early T cell reconstition therapy to combine with HSCT to treat and cure patients with hematological cancers. In this stage, thus for this project, we need to investigate if we can make in vitro T cell from CD34+…
1) To diagnose occurrence and details (form, size, location) of cyst formation or other MRI abnormalities in patients with Ceramic-on-Polyethylene bearings; 2) To correlate these findings to the clinical status of the patient; .
The primary objective is the safety and feasibility of CEA/frameshift derived neopeptide loaded DC in patient with MSI-positive colorectal cancer and persons who are known to be carrier of a germline MMR-gene mutation with no signs of disease yet.…
The objective of this study is to assess fatigue, physical activity, psychological wellbeing and quality of life in breast cancer patients during and shortly after adjuvant chemotherapy. We will study how often en how intense the symptoms occur. We…
Primary objective • To explore changes in left ventricular ejection fraction (LVEF) values before, during and after trastuzumab treatment Secondary objectives• To explore the reversibility of congestive heart failure associated with trastuzumab…
Primary:The primary objective is to determine the safety and tolerability of the combination treatment, i.e. GCb, VPA and GCV, by evaluation of adverse events (AE*s) serious adverse events (SAE*s) and all clinically significant changes in clinical…
The primary objective of the study is to determine the rate of majorbleeding events in cancer subjects receiving extended treatment withdalteparin (> 6 months and up to 12 months) for prevention ofrecurrent symptomatic venous thromboembolism…
To study the influence of hepatic impairment on plasma pharmacokinetic parameters of eribulin mesylate (E7389) following an IV administration.
Primary objective:To determine the pharmacokinetics of E7080 and its excretion balance in order to elucidate its metabolic profile in plasma, urine, and feces following a single oral dose of radiolabeled 14C-E7080 in patients with advanced tumors or…