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Safe Stop IPI-NIVO Trial: Early discontinuation of nivolumab upon achieving a (confirmed) complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab

This study has been transitioned to CTIS with ID 2024-516938-34-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the rate of ongoing response at 12 months after start of treatment in patients with…

At-home Monitoring of patients during Chemoradiation for Oesophageal canceR: the AMCOR trial

To determine the feasibility of at-home monitoring patients with oesophageal cancer during chemoradiotherapy.

A first-in-human, open-label, dose escalation followed by dose expansion phase I/IIa trial to evaluate the safety, preliminary efficacy and pharmacokinetics of intratumoral CyPep-1 monotherapy and in combination with pembrolizumab in patients with advanced solid cancers.

The primary objectives are:- To evaluate the safety and tolerability of IT administration of CyPep-1 as monotherapy and in combination with pembrolizumab.- To identify the recommended phase II dose (RP2D) of CyPep-1 as monotherapy and in combination…

Administration of immune checkpoint inhibitors through an elastomeric pump. A patient preference study and cost analysis.

The primary objective of this study is to evaluate the patient preference for either ICI-B or ICI-P. Secondary objectives are: to assess patient satisfaction with ICI-B and ICI-P, to establish the safety of ICI-B and ICI-P to establish the…

COMPRehensive assessment of prevalence, risk factors and mechanisms of impaired medical and psychosocial health outcomes among Adolescents and Young Adults with cancer: the prospective observational COMPRAYA cohort study

To examine the prevalence, risk factors and mechanisms of impaired health outcomes (short- and long-term medical and psychosocial effects and late effects) over time among a population-based sample of AYA cancer patients.Primary Objective: - To…

Validation of ICG-99mTc-nanoscan as hybrid tracer for sentinel node biopsy

This study has been transitioned to CTIS with ID 2024-519351-28-00 check the CTIS register for the current data. Cross validation of the hybrid tracer ICG 99 Tc Nanoscan with respect to 99m Tc Nanoscan for the determination. In particular the…

A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Study of Investigational Agents With or Without Pembrolizumab in Participants with PD-1/L1 Refractory Locally Advanced or Metastatic Urothelial Carcinoma (KEYMAKER-U04): Substudy 04A

This study has been transitioned to CTIS with ID 2023-506384-34-00 check the CTIS register for the current data. Primary:- To assess the safety and tolerability of MK2140- To evaluate objective response rate (ORR) of MK2140 as assessed by BICR per…

A single-center, open-label study to evaluate the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetics of [14C]JDQ443 following a single oral dose of JDQ443 in healthy male participants.

In this study, we will investigate how quickly and to what extent JDQ443 is absorbed, transported, and eliminated from the body. JDQ443 will be radioactively labeled with carbon-14 (14C). In this way, JDQ443 can be traced in blood, urine, feces, and…

Individualisation of management with novel upfront therapy enzalutamide in newly diagnosed metastasized prostate cancer using (PSMA)PET/CT imaging

To assess the predictive value of early response measurements on PSMA-PET/CT for therapy success, defined as time to development of castration-resistant prostate cancer (CRPC), in order to personalize treatment choice.

Superparamagnetic iron oxide-enhanced magnetic resonance imaging for sentinel lymph node identification in oral cancer: a feasibility study

To explore the feasibility of sentinel lymph node identification by SPIO injection followed by MRI in head-and-neck cancer patients.

Evaluation of a home-based prehabilitation program for high-risk patients undergoing major elective abdominal surgery: a one-group pre-test post-test pilot study.

The primary objective of this one-group pre-test post-test pilot study is to assess the feasibility of a home-based personalized prehabilitation program of approximately four weeks (usual care) in high-risk patients scheduled for elective colorectal…

Magnetic marker localisation for non-palpable breast cancer.

The primary objective of this study is to determine the competence of a magnetic marker as a technique to localise non-palpable breast cancer, measured through retrieval rate using only the magnetic probe. The secondary objectives of this study are…

A phase I dose finding study of oral LXH254 in adult patients with advanced solid tumors harboring MAPK pathway alterations.

Primary: To characterize the safety and tolerability of LXH254 single agent and to identify recommended doses for future studies in adult patients with advanced solid tumors harboring MAPK pathway alterations.To characterize the safety and…

An exploratory tumor biopsy-driven study to understand the relationship between biomarkers and indicators of clinical response in immunomodulatory treatment naïve unresectable stage III/IV melanoma patients receiving REGN2810 (anti-PD-1)

The primary objective of the exploratory study is to characterize the types and dynamics of changes in the tumor microenvironment that occur following programmed-death-1 (PD-1) receptor blockade with REGN2810 and to assess their relationship to the…

A single-center, open-label study to investigate the absorption, distribution, metabolism and excretion (ADME) of HDM201 (Siremadlin) after a single oral dose of 25 mg [14C]HDM201 in healthy subjects

The purpose of this study is to investigate how quickly and to what extent HDM201 is absorbed, broken down and eliminated from the body (this is called pharmacokinetics). HDM201 will be labeled with 14-carbon (14C) and is thus radioactive. In this…

18F-PSMA-1007 PET to detect primary prostate cancer: a comparative study with mpMRI and correlation to histopathology

This explorative study aims to investigate the added value of a 18F-PSMA PET to mpMRI in the detection of local prostate cancer lesions.

A prospective, Phase 3, multi center, single-arm, imaging study investigating the safety and diagnostic performance of rhPSMA 7.3 (18F) PET ligand in men with suspected prostate cancer recurrence based on elevated PSA following prior therapy

To assess the patient level CDR and region level PPV of rhPSMA-7.3 (18F) PET for BCR of PCa using histopathology or imaging as a SoT. Secondary Objectives: 1. To assess the patient level CDR and region level PPV of rhPSMA-7.3 (18F) PET in the…

CT-venography compared to duplex ultrasound for detection of catheter-related thrombosis in cancer patients

The main objectives of this study are(I) to compare the sensitivity of CT-venography and ultrasound for screening-detected, catheter-related thrombosis in cancer patients and (II) to assess intrinsic coagulation levels in cancer patients prior to…

Intra-operative pelvic vessel and bone acquisition, towards ultrasound registration for surgical navigation

Primary objective: - To develop an automatic segmentation algorithm using artificial intelligence for real-time intra-operative pelvic vessel segmentationSecondary objectives: - Post-operative evaluating the accuracy of different registration…

Utilizing magnetic nanoparticles in prostate cancer for sentinel and aberrant lymph node mapping

The primary goal is to increase the available information for the surgeon by providing an extensive lymph node map of the patient. The secondary goal is to compare two magnetic detectors for the further development of a laparoscopic version. The…