212 results
Primary Objective: To study the feasibility of Velocity Selective Arterial Spin Labeling as a non-invasive technique for breast cancer screening by comparing image quality with DCE-MRI.Secondary Objectives: Comparing tumor characteristics and…
Safety ObjectiveThe safety objective for this study is as follows:* To evaluate the safety and tolerability of atezolizumab in pediatric and young adult patients, focusing on the nature, frequency, and severity of serious and non-serious adverse…
To evaluate the influence of anticoagulant treatment on the platelet mRNA profile in patients in whom anticoagulation is initiated.
To test if the NIPT approach is capable of detecting ctDNA in patients diagnosed with four different types of cancer.
Primary Objective: - The ability of SFR spectroscopy incorporated in EUS-FNA procedure in distinguishing benign and malignant pancreatic tissue by measuring wavelength dependent optical characteristics over a broad wavelength range (400-1000 nm).…
Develop and evaluate the potential of TEPs and ctDNA as a novel liquid biomarker for early ovarium cancer diagnostics. And to evaluate the accuracy of ctNDA on response evaluation in patients with ovarian carcinoma.
Primary Objective: To characterize the effect of repeat-dose administration of brigatinib 180 mg QD on the single-dose PK of midazolam.Other Objectives:Safety: To assess the safety and tolerability of brigatinib in patients with ALK-positive or ROS1…
To evaluate the safety and efficacy of 177Lu-PSMA RLT in patients with R/M ACC and SDC with PSMA ligand uptake.
The primary objective is to investigate if ADT can increase the uptake of 68Ga-PSMA in patients with R/M SDC.
Primary objective:To identify novel variants in the DPYD gene in non-Western patients that are related to the occurrence of severe (grade *3) toxicity upon treatment with fluoropyrimidines.Secondary objective:* To determine the influence of novel…
Primary Objective: We want to further develop and evaluate our patients* specific ex vivo LC organoids in which at least 50% of the obtained tumor samples are viable and proliferating at week 2 and 6.Secondary Objective: We will analyse differences…
Investigate the distribution, dosimetry and image quality of [195mPt]cisplatin in cancer patients
This study will provide insights into the role of gut microbes from the upper (saliva) and/or lower GI (rectal/faecal) microbiota in the occurrence of postoperative complications in patients with resectable pancreatic and periampullary presumed (pre…
The overall objective of this study is to develop and evaluate an optimized dosing algorithm (CT-CL) for carboplatin using serum creatinine and CT-derived body composition that can be easily implemented in clinical practice.
The overall aim of this study is to identify and describe distinct recovery trajectories with the innovative digital resilience assessment tool (Orion) in older oncology patients and patients with stage IV lung cancer during systemic therapy.
The purpose of the study is to investigate how quickly and to what extent 2 different production batches of alpelisib (FMI and FMIopt) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…
The primary objective is to explore endothelial function in patients before and after treatment with anthracyclines.
The aim of this pilot is to get an impression of the feasibility and added value of administering deep sound waves to the body during (neo) adjuvant chemotherapy. In addition, we want to gain insight into whether or not complete completion of a…
Determination of the number of tdEVs in plasma and urine in PCa patients at different stages, together with appropriate controls. This will be determined by the use of different EV enumeration and molecular techniques. For comparison, some sample…
The primary objective of this study is to assess presence, number, type, specificity and function of HPV-specific immune response in the peripheral blood, lesions/tumors and their draining lymph nodes of patients at different stages of HPV-induced…