16 results
The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…
To unravel the genetic makeup of colorectal cancer (CRC) in adolescents and young adults (AYAs) in order to improve genetic counseling, surveillance and, ultimately, treatment and disease outcome.
To directly evaluate the gastric tube microcirculation with Dark Sidestream imaging during minimal invasive esophageal resection on several locations, i.e. from best arterial blood supply (antrum) to worst (fundus). Furthermore, to evaluate the…
The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…
To determine the composition of immune cells and the expression of immunological factors in normal squamous esophagus, RE, BE and EAC.
To find procoagulant markers predictive of progression of the underlying malignancy or predictive of the occurrence of a venous thrombotic event.
Primary objective of the study is the assessment of the dose limiting toxicity (DLT) and the maximal tolerated dose (MTD) of capecitabine and mitomycin-C with concomitant SIBRT in patients with locally advanced anal carcinoma.Secondary objectives…
Primary Objectives:1. To compare the protein synthesis of pancreatic, liver, intestinal, fat and muscle tissue and leukocytes in cachectic patients.2. To compare pancreatic malignancy protein synthesis with the protein synthesis in normal pancreatic…
To analyze the gut microbiome in relation to response and toxicity in a prospective cohort of patients with newly diagnosed metastasized or irresectable colorectal carcinoma treated with standard systemic therapy.
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
The primary aim of this study is to compare intrinsic pathway activation between cancer patients with acute VTE and those without VTE. Intrinsic pathway activation will be assessed by measuring coagulation factor complexes with their natural…
To collect biomaterials (peripheral blood, DNA, serum, faeces and intestinal biopsies from IBD patients with dysplastic lesions in the colon to allow research into the immunological pathways leading to dysplasia development.
To investigate whether recently identified patient-specific factors can predict the occurrence of anastomotic leakage in patients undergoing elective surgery for colorectal cancer. Secondary: to develop a predictive model/diagnostic algorithm for…
To establish the diagnostic and predictive value of different biomarkers in patients with pancreatic cancer by the investigation of:- Mutated ct-DNA levels in pancreatic juice and blood.- Chromosomal instability in pancreatic juice and blood.- Pro-…
1. To determine the predictive value of frailty characteristics for loss of HRQL in elderly patients with non-metastatic CRC.2. To develop an AGE-CRC score, a prediction model for loss of HRQL in elderly patients with CRC based on comorbidity, risk…
To develop a prediction model for EOCRC patients that estimates the risk of having low HRQoL one year after inclusion based on a comprehensive set of predictors including patient characteristics, disease and treatment factors, lifestyle variables…