25 results
The primary aim of the study is to assess whether DWI, DCE-MRI, T2*, and 18F-HX4-PET/CT predict overall survival in patients with pancreatic cancer treated with surgery and adjuvant chemotherapy or with neoadjuvant radiochemotherapy, surgery and…
1. To determine the optimal acquisition technique for USPIO enhanced MRI (without contrast injection), DCE (without contrast injection) and DWI and T2* MRI of esophageal cancer in terms of signal-to-noise ratio, time resolution and spatial…
Predictive factors are needed to discriminate chemoradiotherapy responders from non-responders and to individualize the treatment regime. Various cytokines play a role in processes affecting tumour growth and metastasis. Furthermore, cytokines might…
The purpose of this pilot study is twofold: - evaluation of the tumour movement and regression during and short after long course pre-operative therapy for locally advanced rectal cancer in order to develop an integrated or sequential dose…
The identify the health-related quality of life of elderly patients with resected stage III colon cancer and relate the outcomes to patient and treatment characteristics (surgery alone or surgery plus adjuvant chemotherapy). Furthermore, the impact…
Primary Objective:- To determine the incidence of EPI in pancreatic cancer.Secondary Objectives are: 1. To identify the predictive factors for the development of EPI in pancreatic cancer.2. To evaluate the occurrence of nutritional deficiencies in…
To determine whether surgery induces changes in the liver vasculature of patients with colorectal cancer.
To identify circulating mediators that are released after surgery and which are responsible for macrophage activation.
To evaluate the feasibility to assess treatment response on radiochemotherapy for locally advanced rectal cancer by repeated anatomical and functional MRI and FDG-PET.
To quantify rectal tumour motion using (cine-)MRI and to correlate this motion with rectal wall movement in order to check the feasibility for CBCT controlled dose escalation for rectal cancer.
To determine the reproducibility for quantitative analysis of MRI with contrast en diffusion weighted MRI (DWI) if abdominal malignant tumors.
The primary objective of the present study is to obtain insight into the long-term effects of new therapies on the HRQL of colorectal cancer survivors in a population-based setting. Therefore, we will measure the HRQL of newly diagnosed and up to 10…
Assess the feasibility of preoperative treatment with pertuzumab and trastuzumab combined with preoperative chemoradiation (carboplatin, paclitaxel and radiation) in terms of withdrawal rate from surgery
This is a pilot pretest-posttest intervention study to first test feasibility of an intensive, personalized, integrated training program consisting of disease-specific education, in combination with physical exercise and mental coaching in order to…
The feasibility of preparing untreated esophageal adenocarcinoma endoscopic biopsies towards DNA/RNA samples suitable for next-generation sequencing.
To determine which costimulatory and co-inhibitory molecules are expressed on tumor-infiltrating lymphocytes (TIL) derived from patients with CRC (including metastasized CRC), and to study the effects of targeting these molecules on their function…
To determine whether micellar curcumin is able to restore functional lymphocytes in pancreatic cancer patients with stable disease after standard of care treatment.
Primary objectives:To validate the concept that ex vivo organoid response correlates to in vivo response to standard treatment in mCRC patients on a metastasis level.Secondary objectives:• Relate organoid results to response to treatment on a…
Establish the immunogenicity of tumor organoids in vitro
We aim to determine the validity of the steep ramp test as practical performance-based aerobic capacity test in patients undergoing elective colorectal resection by correlating the tests* scores with the ventilatory anaerobic threshold and oxygen…